Cell Cycle Inhibition by FoxO Forkhead Transcription Factors Involves Downregulation of Cyclin D

By Marc Schmidt, Sylvia Fernandez de Mattos, Armando van der Horst, R. Klompmaker, G. Kops, E. Lam, B. Burgering, R. Medema. Molecular and Cellular Biology, 2002

612 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4de0c991aa6bbdbd5a38cd9211ae8b3d2b9346ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. E. L. Greer
2. A. Brunet
3. R. DePinho

In Molecular Biology

1. Ping Wee
2. Zhixiang Wang
3. E. L. Greer
4. A. Brunet
5. R. DePinho
6. R. Shaw

Citations in the corpus

• FOXO transcription factors at the interface between longevity and tumor suppression (2005, background): “Interestingly, FOXO factors can also promote cell cycle arrest by repressing the expression of cyclin D1 and D2, two cell cycle positive regulators (Ramaswamy et al., 2002; Schmidt et al., 2002).”
• Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways (2017, background): “Active FOXO1 (also known as FKHR) transcription factors repress CYCLIN D1 expression [452].”
• Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. (2005, background): “FOXO1 activity controls cell cycle progression (42), in part by stimulating expression of the cyclindependent kinase inhibitor p27 and repressing that of cyclin D1 (43, 44).”
• FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis (2009, background): “…and their family members (e.g., Cyclin D1, Inhibitor of DNA binding 1 and 2, and Polo-like kinase 2) (Alvarez et al., 2001; Birkenkamp et al., 2007; Schmidt et al., 2002) as well as many potential novel FoxO targets that relate well to our biological observations including cell cycle (e.g., G two…”