Pax5: the guardian of B cell identity and function

By C. Cobaleda, A. Schebesta, Alessio Delogu, M. Busslinger. Nature Immunology, 2007

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Sequence and chromatin determinants of cell-type–specific transcription factor binding (2012, background): “In contrast, factors such as PAX5 and EP300 are much better predicted by DNase than sequence signal, which is likely due to their ability to bind indirectly to enhancers and to highly degenerate sequences (Cobaleda et al. 2007; Visel et al. 2009).”
Germinal centres: role in B-cell physiology and malignancy (2008, background): “The terminal differentiation of a B cell into a plasma cell requires the functional inactivation of the transcriptional repressor PAX5, which is essential for maintaining the identity of mature B cells, including naive, GC and memory B cell”
Discovery and Characterization of Super-Enhancer Associated Dependencies in Diffuse Large B-Cell Lymphoma (2013, positive): “In fact, mice with genetic ablation of POU2AF1, BCL6, PAX5, or IRF8 lack the ability to form germinal centers, the physiological structures from which most DLBCLs arise (Cobaleda et al., 2007; Nutt et al., 2011; Teitell, 2003;Wang et al., 2008; Ye et al., 1997).”