Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

By Naotada Ishihara, Y. Fujita, T. Oka, K. Mihara. EMBO Journal, 2006

903 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/35845affdd7703ae344067d71674e4e64905a5ee

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Citations in the corpus

Mitochondrial dynamics and mitochondrial quality control (2014, background): “Presenilin-associatedrhomboid-like (PARL) [13] and paraplegin (an AAA protease present in the mitochondrial matrix) [14] induce alternative splicing and alternative processing of OPA1 to generate eight OPA1 isoforms.”
Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. (2008, neutral): “presenilin-associated rhomboid-like protease (PARL), m-AAA Paraplegin, and AFG3L2 proteases inmammals [69,72,73].”
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy (2008, background): “Recently, a protonophore-induced complete collapse of Dcm of the entire cell mitochondria was shown to trigger proteolytic cleavage or degradation of OPA1 long (l-)isoforms (Griparic et al, 2004; Duvezin-Caubet et al, 2006; Ishihara et al, 2006; Song et al, 2007).”
Mitochondrial dynamics and apoptosis. (2008, background): “2006), parapalegin (Ishihara et al. 2006), and Yme1 (Griparic et al.”
Mitochondrial dynamics in mammalian health and disease. (2009, background): “To date, the main identified role for PARL is the generation of a soluble Opa1 isoform detected in the intermembrane space (IMS), which represents 4% of total IMS Opa1 in mitochondria (60, 101).”
Cellular and molecular mechanisms of mitochondrial function (2012, background): “56 58 The ability of OPA1 to self-interact and oligomerize requires both L-OPA1 and S-OPA isoforms.”
Metabolic regulation of mitochondrial dynamics (2016, background): “ 2; Ishihara et al., 2006) owing to activation of Oma1 (Ehses et al., 2009; Head et al., 2009).”
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, background): “Treatment of cultured cells with a protonophore, CCCP, leads to rapid mitochondrial fragmentation (Ishihara et al., 2006).”
Mitophagy: mechanisms, pathophysiological roles, and analysis (2012, background): “It has been suggested that the rhomboid-related protease, presenilins-associated rhomboidlike (PARL) (Cipolat et al. , 2006 ), or the AAA protease in the matrix, paraplegin, may be responsible for OPA1 processing (Ishihara et al. , 2006 ).”
OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L (2007, positive): “Long forms of OPA1 isoforms 1 and 2 in isolation have little or no fusion activity Previous experiments suggested that the long form of isoform 1 is the fusion-active species (Ishihara et al., 2006).”
The Interplay Between Mitochondrial Dynamics and Mitophagy (2011, background): “In mammalian cells, the long isoforms (high molecular weight) of Opa1 undergo cleavage (or degradation) when depolarization is induced or ATP is depleted (25, 32, 40, 57, 101).”
The role of mitochondria in apoptosis. (2008, neutral): “Opa1 Parl Proteolytic processing (9) Paraplegin Proteolytic processing (111) Yme1L Proteolytic processing (112)”