Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease.

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Mitochondrial defects and oxidative stress in Alzheimer disease and Parkinson disease (2012, background): “[97] also found fragmented mitochondria and an altered expression of mitochondrial fission/fusion proteins in primary neurons isolated Yan et al.”
Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease (2017, background): “Further, increased levels of A could accelerate a production of ROS by directly binding to mitochondrial membranes, altering mitochondrial dynamics and function, ultimately leading to the abnormal energy metabolism and the loss of synaptic function [35, 37, 39, 46, 62, 125, 126].”