Resolution of Lung Inflammation by CD44

By P. Teder, R. Vandivier, D. Jiang, Jiurong Liang, L. Cohn, E. Puré, P. Henson, P. Noble. Science, 2002

725 citations recorded by the source corpus.

Subfields: Cancer Research, Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/894d32939a43800e99d9f50c7ce4c87c5471652e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Nikolaos G. Frangogiannis
2. P. Noble
3. B. Toole
4. Jiurong Liang
5. R. Medzhitov
6. S. Eming
7. J. Powell
8. D. Jiang

In Cell Biology

1. Nikolaos G. Frangogiannis
2. R. Medzhitov
3. B. Toole
4. R. Gallo
5. S. Eming
6. K. Taylor
7. A. Varki
8. K. Girish

In Immunology and Allergy

1. Nikolaos G. Frangogiannis
2. P. Noble
3. B. Toole
4. Jiurong Liang
5. R. Medzhitov
6. D. Jiang

Citations in the corpus

• CD44: From adhesion molecules to signalling regulators (2003, background): “In another study, intratracheal application of bleomycin caused the accumulation of excess apoptotic neutrophils and pro-inflammatory hyaluronan fragment”
• Points of control in inflammation (2002, background): “Some of the signals involved are revealed by the failure of mice to resolve late-phase inflammation when they are deficient in the CD44 hyaluronan recepto”
• Hyaluronan as an Immune Regulator in Human Diseases (2011, positive): “Our laboratory has demonstrated that CD44 is required for the resolution of pulmonary inflammation (449).”
• Pathophysiology of Myocardial Infarction (2015, positive): “Hyaluro-nan participates in induction and resolution of inflammation through interactions with the transmembrane adhesion molecule CD44 (290,362), a ubiquitously distributed glycoprotein that mediates a wide variety of cell-cell and cell-matrix interactions.”
• Inflammatory Resolution: new opportunities for drug discovery (2004, background): “Indeed, there is already evidence in animal models that CD44 has an important role in resolving lung inflammatio”
• Inflammation in wound repair: molecular and cellular mechanisms. (2007, background): “Such mechanisms might include: downregulation of chemokine expression by anti-inflammatory cytokines such as IL-10 (Sato et al., 1999) or TGF-b1 (Ashcroft et al., 1999a, 1999b; Werner et al., 2000), or upregulation of anti-inflammatory molecules like IL-1 receptor antagonist or soluble TNF receptor;”
• Hyaluronan: from extracellular glue to pericellular cue (2004, background): “CD44 also mediates the cellular uptake and degradation of hyaluronan, which in turn affects growth regulation and tissue integrit”
• Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer (2015, background): “Thus, HMW HA in the ECM degraded by HYALs into smaller fragments can still bind to CD44 (221).”
• Hyaluronan fragments: an information-rich system. (2006, background): “This has been particularly well demonstrated following experimental lung injury (Teder et al., 2002; Jiang et al., 2005).”
• CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, background): “Wild-type (BALB/c or C57/Bl6), CD74-KO (Shachar and Flavell, 1996), CD44-KO (Teder et al., 2002), and MIF-KO (Bozza et al.”
• Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR21 (2006, background): “Inasmuch as CD44 is a receptor for HA, this increase in disease susceptibility has been attributed to the inability of CD44 macrophages to clear LMW HA (22).”
• Glycosaminoglycans and their proteoglycans: host‐associated molecular patterns for initiation and modulation of inflammation (2006, background): “Wild-type mice possessed LMW HA after injury that eventually returned to HMW HA, whereas CD44-deficient mice had a variety of HA oligosaccharide sizes that did not exist in the wild-type mice (108).”