CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.

By Xuerong Shi, L. Leng, Tian Wang, Wenkui Wang, Xin Du, Ji Li, Courtney McDonald, Zun Chen, James W. Murphy, E. Lolis and 3 more. Immunity, 2006

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Cytokines in Sepsis: Potent Immunoregulators and Potential Therapeutic Targets—An Updated View (2013, background): “MIF activates immune cells by binding to CD74 (the cell surface form of the class IIassociated invariant chain), which leads to the recruitment of CD44 into a signaling complex and the downstream initiation of the ERK1/2 MAP kinase pathway [163, 164].”
Harmful molecular mechanisms in sepsis (2008, background): “, the CD74 receptor complex has also been described to function as a MIF receptor, from which signals are transduced through CD44 (Ref”
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment (2007, background): “CD74 (also known as invariant chain) binds MIF on the surface of cells, can mediate activation of extracellular-regulated mitogen-activated protein (ERK-MAP) kinases and associates into a signaling complex with MIF, CD44 and Src-tyrosine kinase”