Inflammation in wound repair: molecular and cellular mechanisms.

By S. Eming, T. Krieg, J. Davidson. Journal of Investigative Dermatology, 2007

2,309 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Occupational Therapy, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/00f70fbc8c9f718955ae69a36cefead93f3f53b9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

In Occupational Therapy

In Rehabilitation

Citations in the corpus

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing (2017, background): “The repair process is highly complex, consisting of four stages: haemostasis, followed by inflammatory, proliferative and remodeling phases, that involve complex interactions between skin cells, immune cells and extracellular matrix (ECM) components, as well as a plethora of soluble mediators that h”
Immunobiology of mesenchymal stem cells (2013, background): “cells, not only macrophages and neutrophils but also adaptive immune cells, including CD4þ T cells, CD8þ T cells and B cells, which are recruited by factors from apoptotic cells, necrotic cells, damaged microvasculature and stroma.(19,20) Meanwhile, inflammatory mediators, such as TNF-a, IL-1b, free”
Inflammation in Chronic Wounds (2016, background): “This delay in wound healing also exacerbates scarring due to prolonged inflammation, and is predisposed to neoplastic progression [49,50].”
Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice (2010, background): “Inflammation is tightly regulated by the following two types of signals: i) initiate & maintain inflammation; and ii) resolve inflammation [23].”
Macrophages in skin injury and repair. (2011, neutral): “None of these phases corresponds to a precisely efined period of time and all phases overlap (Eming et al. 2007). hen this complex process proceeds normally, a normotrophic car is formed.”
Wound repair and regeneration: Mechanisms, signaling, and translation (2014, positive): “…and functional alterations of the lower leg, and ultimately skin ulceration, remain unknown, although recent findings provide several theories including persistent inflammation, interruption of keratinocyte migration, and misregulated signaling and/or expression of specific microRNAs (6-9).”
Transition from inflammation to proliferation: a critical step during wound healing (2016, background): “less about how inflammation is resolved during normal wound healing, which is prerequisite for understanding the pathogenesis of persistent inflammation in chronic wounds [6].”
Epithelialization in Wound Healing: A Comprehensive Review (2014, background): “The inflammatory phase of wound healing continues with active recruitment of macrophages from blood vessels, which is orchestrated by growth factor signals from keratinocytes, and by foreign epitopes of microorganisms.(72) The macrophage chemoattractant protein (MCP-1), a member of the CC family of ”
Acute and Impaired Wound Healing: Pathophysiology and Current Methods for Drug Delivery, Part 1: Normal and Chronic Wounds: Biology, Causes, and Approaches to Care (2012, background): “induce production of serine proteinases and MMPs that degrade and inactivate components of the ECM and growth factors necessary for normal cell function.(7) Inactivation of proteinase inhibitors by proteolytic degradation augments this process.”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “Neutrophils and monocyte-macrophages cooperate as partners in time and space during the initiation, evolution, and resolution of the inflammatory phase [76].”
Differential Roles of Macrophages in Diverse Phases of Skin Repair (2010, background): “Indeed, imbalanced inflammation characterized by increased numbers of macrophages is a hallmark of an attenuated repair response in human diseases encompassing diabetes mellitus, vascular disease, and aging (7, 8).”