CD44: From adhesion molecules to signalling regulators

By H. Ponta, L. Sherman, P. Herrlich. Nature reviews. Molecular cell biology, 2003

2,475 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/647a73b6808c2e4824bd7e747f1b18e9ca308ab5

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Citations in the corpus

CD44: can a cancer-initiating cell profit from an abundantly expressed molecule? (2011, background): “There are excellent reviews on the multiple pathways through which CD44 is involved in signal transductio”
Pathophysiology of Myocardial Infarction (2015, positive): “Hyaluro-nan participates in induction and resolution of inflammation through interactions with the transmembrane adhesion molecule CD44 (290,362), a ubiquitously distributed glycoprotein that mediates a wide variety of cell-cell and cell-matrix interactions.”
MET signalling: principles and functions in development, organ regeneration and cancer (2010, background): “Another protein that cooperates with MET in normal and transformed epithelial cells is CD44, a transmembrane cell adhesion molecule that functions as a linker between the extracellular matrix and the intracellular actin cytoskeleto”
Identification of Gastric Cancer Stem Cells Using the Cell Surface Marker CD44 (2009, background): “As previously reported [27], CD44 is the receptor for hyaluronic acid (HA), one of the extracellular matrix components, and we confirmed CD44 expressed in these cell lines bound to HA (supporting information Fig.”
The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. (2007, background): “, 2004), RHO GTPases (Ponta et al., 2003), VAV2, GAB1, ezrin (Toole, 2004), and ankyrin (Zhu and Bourguignon, 2000).”
Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies (2020, background): “Its expression is associated with increased proliferation, self-renewal and metastasis (61, 149, 462, 463).”
Organizing the Cell Cortex: The role of ERM proteins (2010, background): “Some studies of CD44 in tumour invasion suggest that its role is directly related to its function as a receptor for hyaluronic acid, which is often concentrated at the invasive front of tumours and may be important in cancer stem cell–niche interaction”
Hyaluronan fragments: an information-rich system. (2006, background): “Binding is by the predominant HA receptors, CD44 (Lesley et al., 2000; Ponta et al., 2003) and receptor for HAmediated motility (RHAMM) (Zhang et al.”
The biology and role of CD44 in cancer progression: therapeutic implications (2018, background): “HA binds the CD44 ligand binding domain inducing conformational changes that allow binding of adaptor proteins or cytoskeletal elements to intracellular domains that in turn activate various signaling pathways leading to cell proliferation, adhesion, migration, and invasion [7, 8].”
Extracellular matrix structure. (2016, background): “at its ectodomain close to the cell surface, and this structural feature is responsible for the binding of growth factors, such as VEGF and HGF, to CD44 variant isoforms [334, 335].”
CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. (2006, background): “In addition, MIF activates the ERK effectors cytoplasmic phospholipase A2, which initiates arachidonic metabolism and has a role in p53 suppression (Mitchell et al., 2002), and the Elk-1 and Ets transcription factors, which regulate TLR4 expression (Roger et al., 2001).”
Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells (2006, background): “CD44, which is spliced into many isoforms, is an adhesion molecule with multiple signaling functions (Ponta et al., 2003).”