Morphogenesis and renewal of hair follicles from adult multipotent stem cells.

By H. Oshima, A. Rochat, Cécile Kedzia, Koji Kobayashi, Y. Barrandon. Cell, 2001

1,035 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Urology

View Paper: https://www.semanticscholar.org/paper/8815ce1224f062442ab45e0e230da116a84cb381

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Elaine Fuchs
2. C. Blanpain
3. Hans Clevers
4. H. Pasolli
5. V. Horsley
6. Linheng Li
7. A. Trumpp
8. Anne Wilson

In Molecular Biology

1. Hans Clevers
2. Elaine Fuchs
3. C. Blanpain
4. Linheng Li
5. V. Horsley
6. W. Birchmeier
7. Hugo J. G. Snippert
8. Nick Barker

In Urology

1. Elaine Fuchs
2. Hans Clevers
3. C. Blanpain
4. Linheng Li
5. H. Pasolli
6. V. Horsley
7. Hugo J. G. Snippert
8. Y. Hsu

Citations in the corpus

• Keratinocyte-fibroblast interactions in wound healing. (2007, background): “marker expression (Barrandon and Green, 1987; Cotsarelis et al., 1990; Oshima et al., 2001; Tumbar et al., 2004; Jensen and Watt, 2006), nevertheless their exact nature still remains somewhat elusive.”
• Characterization and isolation of stem cell-enriched human hair follicle bulge cells. (2005, background): “Accumulated evidence subsequently confirmed that, in rodents, the bulge is the repository of multipotent stem cells that support hair follicle cycling and repopulate interfollicular epidermis and sebaceous epithelium (6, 7, 9–11).”
• Capturing and profiling adult hair follicle stem cells (2004, background): “Hair follicle stem cells are thought to reside at the base of the telogen follicle in an area called the bulg”
• Tissue engineering of replacement skin: the crossroads of biomaterials, wound healing, embryonic development, stem cells and regeneration (2007, background): “Other studies have shown that when the bulge cells of a normal mouse are surgically replaced with cells from a lac-Z mouse, the new chimeric hair follicles ubiquitously express lac-Z within all lineages of the hair follicle (Oshima et al. 2001).”
• A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration (2009, positive): “In the adult skin, slowcycling, relatively undifferentiated SCs exist within a niche known as the bulge, located below the sebaceous gland in the outer root sheath (ORS) of the hair follicle (HF) (Cotsarelis et al., 1990; Oshima et al., 2001; Taylor et al., 2000).”
• Bone-marrow haematopoietic-stem-cell niches (2006, background): “For example, such label-retaining cells (LRCs) were initially identified using BrdU in the hair-follicle bulge in the skin, leading to the suggestion that ESCs were present in this structur”
• Cellular and molecular mechanisms of skin wound healing (2024, neutral): “Hair follicle stem cells can regenerate the follicle at every growth phase 52,53 and can regenerate the follicle and interfollicular epidermis after transplantation 54–58 .”
• β-Catenin Controls Hair Follicle Morphogenesis and Stem Cell Differentiation in the Skin (2001, positive): “In the adult, hair follicles undergo continuous self-renewal and cycling, which depend on pluripotent stem cells that reside in the bulge of the hair follicles, a portion of the outer root sheath [15,16,23,83,42, 59 ].”
• Getting under the skin of epidermal morphogenesis (2002, background): “These stem cells are MULTIPOTENT and can give rise not only to epidermis, but also to hair follicles and sebaceous gland”
• Burn wound healing and treatment: review and advancements (2015, background): “The use of enriched population epidermal stem cells for the preparation of cultured grafts for patients offers hope of overcoming several limitations of current skin substitutes as in a suitable microenvironment, keratinocyte stem cells can also form appendages such as hair, epidermis and sebaceous ”
• Socializing with the neighbors: stem cells and their niche. (2004, background): “…differentiating imbalance achieved and how is it spatially oriented?cells are lost in the homeostatic flux of tissue turnover The overall problem can be conceptualized by linking(Taylor et al., 2000; Oshima et al., 2001 and references three distinct mechanisms: (1) the generation of celltherein).”
• Lgr5 marks cycling, yet long-lived, hair follicle stem cells (2008, background): “At certain hair follicle stages, the lower portions of mouse vibrissa follicles contain cells that can reconstitute a complete hair follicle upon transplantatio”
• Wnt signaling in development and tissue homeostasis (2018, background): “During the telogen-anagen transition, Wnt-β -catenin activity in the bulge HFSCs increases (Lien et al., 2014) and cells from the bulge migrate to the base of the hair follicle and begin proliferating rapidly to produce cell lineages of a new hair follicle (Oshima et al., 2001; Tumbar et al., 2004).”