Keratinocyte-fibroblast interactions in wound healing.

By S. Werner, T. Krieg, H. Smola. Journal of Investigative Dermatology, 2007

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Burn wound healing and treatment: review and advancements (2015, background): “Following, and overlapping with the inflammatory response, the proliferative phase is characterized by keratinocyte and fibroblast activation by cytokines and growth factors [34].”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “Simultaneously, an active paracrine interaction between keratinocytes, fibroblasts, neutrophils, monocytes-macrophages, and endothelial cells increases the amount of cytokines, growth factors, and other biomolecules to promote the epithelial-mesenchymal interaction between keratinocytes and fibrobla”
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “In addition, fibroblasts are also critical for the homeostasis of adjacent epithelial cells, acting in an indirect paracrine manner, similar to that of growth factors(27,28) or via direct mesenchymal–epithelial cell interactions.(29,30) In angiogenesis with increased production of vascular endotheli”
Differential Roles of Macrophages in Diverse Phases of Skin Repair (2010, background): “Contemporaneously to the formation of granulation tissue, at the wound edge, complex epidermal-mesenchymal interactions stimulate keratinocyte proliferation and migration to restore the epidermal barrier (5).”