Lgr5 marks cycling, yet long-lived, hair follicle stem cells

By V. Jaks, Nick Barker, M. Kasper, J. V. Es, Hugo J. G. Snippert, Hans Clevers, R. Toftgård. Nature Genetics, 2008

977 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology, Urology

View Paper: https://www.semanticscholar.org/paper/799d8f36c31d158ef4c45c95aafe2a5a6d8563b1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Hans Clevers
2. R. Nusse
3. Elaine Fuchs
4. C. Blanpain

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Elaine Fuchs
4. C. Blanpain
5. Nick Barker
6. Hugo J. G. Snippert
7. H. Pasolli
8. Toshiro Sato

In Urology

1. Elaine Fuchs
2. Hans Clevers
3. C. Blanpain
4. H. Pasolli
5. R. Nusse
6. Y. Hsu
7. Hugo J. G. Snippert
8. N. Stokes

Citations in the corpus

• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “Intestine Crypt base columnar cell Lgr5 (25) Mammary gland Basal cell Axin2, Lgr5 (24, 50–53) Stomach Basal pyloric cell Lgr5 (85) Interfollicular epidermis Basal cell Axin2 (44, 45) Central nervous system Radial glial cell Axin2 (98) Hair follicle Outer bulge cell Lgr5 (99) Kidney Nephron segment-s”
• Tracking adult stem cells (2011, methodology): “By using the Lgr5 knock-in mouse, actual stemness has been shown for LGR5+ cells in the stomach, small intestine, colon and the hair follicle (Barker et al, 2007, 2010; Jaks et al, 2008).”
• A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration (2009, positive): “The recent Lgr5 lineage tracing goes one step further in demonstrating that the stem cell potential of Lgr5-marked bulge/HG cells is long term (Jaks et al., 2008).”
• Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “Regional and temporal variation in cycling behaviour has been described among bulge SC”
• Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “Using the same lineage-tracing strategy, Lgr5 was subsequently demonstrated to mark stem cells in many other organs and tissues, including the hair follicle (Jaks et al., 2008), stomach (Barker et al.”
• Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (2010, positive): “In the colon, stomach, and hair follicle, Lgr5 cells have also been identified as stem cells (Barker et al., 2007, Barker et al., 2010; Jaks et al., 2008), whereas the Lgr6 gene marks a population of primitive skin stem cells (Snippert et al.”
• Wnt/β-catenin signaling and disease. (2012, positive): “It was subsequently found that Lgr5 is a Wnt target gene in colon cancer and that it marks adult stem cells in a number of actively self-renewing organs, including the intestinal tract and the hair follicle (Barker et al., 2009, 2010; Jaks et al., 2008).”
• Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013, positive): “The Wnt target gene Lgr5 marks actively dividing stem cells in Wnt-driven, continuously self-renewing tissues such as small intestine and colon (Barker et al , 2007), stomach (Barker et al , 2010) and hair follicles (Jaks et al , 2008).”
• Sox2+ adult stem/progenitor cells are important for tissue regeneration and survival of mice (2011, neutral): “Sox2 (arrowhead) and Lgr5-EGFP (pink) IHC signals appear to mark different cells in pyloric glands.”
• Regulatory T cells in Skin Facilitate Epithelial Stem Cell Differentiation (2017, positive): “…RNA sequencing (RNA-seq) of bulge HFSCs. Lineage tracing studies in the SC niche have identified a role for ITGA6-expressing basal cell progenitors and their progeny in adopting a HF fate (Ito et al., 2005; Jaks et al., 2008; Levy et al., 2005; Morris et al., 2004; Tumbar et al., 2004).”