Wnt signaling in development and tissue homeostasis

By Z. Steinhart, S. Angers. Development, 2018

724 citations recorded by the source corpus.

ABSTRACT The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication system that is important for stem cell renewal, cell proliferation and cell differentiation both during embryogenesis and during adult tissue homeostasis. Genetic or epigenetic events leading to hypo- or hyper-activation of the Wnt-β-catenin signaling cascade have also been associated with human diseases such as cancer. Understanding how this pathway functions is thus integral for developing therapies to treat diseases or for regenerative medicine approaches. Here, and in the accompanying poster, we provide an overview of Wnt-β-catenin signaling and briefly highlight its key functions during development and adult tissue homeostasis. Summary: An overview of Wnt-β-catenin signaling highlighting its key functions during development and adult tissue homeostasis.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/89d353b4446aa360a3bef1fa0111a906c56f1aea

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1. Haibo Xu
2. Maolun Liu
3. Shan Ren
4. Han Yang
5. Tianqi Ming
6. Shunlei Tang
7. Qiu Tao
8. Hui-Ying Zhao

Citations in the corpus

• Wnt signaling in colorectal cancer: pathogenic role and therapeutic target (2022, background): “Therefore, understanding the function of this pathway is essential for developing therapies to treat diseases or regenerative medicine methods [15].”