Getting under the skin of epidermal morphogenesis

By Elaine Fuchs, Srikala Raghavan. Nature reviews genetics, 2002

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Mechanisms of cutaneous toxicities to EGFR inhibitors (2006, background): “The epidermis is primarily composed of keratinocytes, which undergo a highly regulated process of differentiation and migration towards the skin surfac”
UV Radiation and the Skin (2013, background): “The epidermis, demarcated from the dermis by a basement membrane, is organized into functional layers defined largely by keratinocyte characteristics such as size, shape, nucleation and keratin expression [7] (Figure 1).”
A dermal niche for multipotent adult skin-derived precursor cells (2004, background): “that is a major locus for regulatory dermal–epidermal interaction”
Epithelial stem cells: turning over new leaves. (2007, positive): “In addition, focal adhesions and hemidesmosomes regulate the dynamics of adhesion and detachment of cells and their underlying ECM, thus mediating cell migration, stratification, and differentiation (Fuchs and Raghavan, 2002; Watt, 2002).”
The skin microbiome (2011, background): “The skin is a continuously self-renewing organ, and squames are constantly shed from the skin surface as the final stage of terminal differentiation, having begun their migration from the basal layer ∼4 weeks earlie”