Bone-marrow haematopoietic-stem-cell niches

By Anne Wilson, A. Trumpp. Nature reviews. Immunology, 2006

1,421 citations recorded by the source corpus.

Adult stem cells hold many promises for future clinical applications and regenerative medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so far, but in vitro expansion has been unsuccessful, limiting the future therapeutic potential of these cells. Here we review recent progress in characterizing the composition of the HSC bone-marrow microenvironment, known as the HSC niche. During homeostasis, HSCs, and therefore putative bone-marrow HSC niches, are located near bone surfaces or are associated with the sinusoidal endothelium. The molecular crosstalk between HSCs and the cellular constituents of these niches is thought to control the balance between HSC self-renewal and differentiation, indicating that future successful expansion of HSCs for therapeutic use will require three-dimensional reconstruction of a stem-cell–niche unit.

Subfields: Genetics, Hematology, Oncology

View Paper: https://www.semanticscholar.org/paper/123d3d92aa4197bf965d1b117ebb3e8e7c63cd5d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. C. Bentzinger
2. P. Frenette
3. S. Morrison
4. Michael A. Rudnicki
5. E. Laurenti
6. G. Oser
7. Lei Ding
8. Anne Wilson

In Hematology

1. S. Morrison
2. P. Frenette
3. J. Dick
4. Lei Ding
5. E. Laurenti
6. Anne Wilson
7. A. Trumpp
8. Jane E. Visvader

In Oncology

1. J. Dick
2. S. Morrison
3. Jane E. Visvader
4. Hans Clevers
5. Antonija Krešo

Citations in the corpus

• Satellite cells and the muscle stem cell niche. (2013, background): “In recent years, adult stem cells and their corresponding niches were identified in numerous tissues including bone marrow (566), brain (322), testis (240), liver (528), intestine (55), heart (302), white fat (441, 519), and skin (174).”
• Mesenchymal stem cells in health and disease (2008, background): “The regulation of HSC quiescence, through the maintenance of HSCs in the G0 phase of the cell cycle in the endosteal niche, and the control of HSC proliferation, differentiation and recruitment in the vascular niche can be ascribed to bone-marrow stromal cell”
• Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, positive): “Moreover, many signaling molecules present at the HSC-niche synapse (Graf and Trumpp, 2007; Wilson and Trumpp, 2006) have been suggested to maintain HSCs in a quiescent state.”
• Endothelial and perivascular cells maintain haematopoietic stem cells (2012, background): “One popular model of the HSC niche proposed that osteoblasts express many factors that promote HSC maintenanc”
• Building muscle: molecular regulation of myogenesis. (2012, background): “Satellite cells seem to be particularly sensitive to such manipulation when compared, for example, with hematopoietic stem cells (HSCs), which after release can home back to their niche relatively efficiently while maintaining their stemness (Wilson and Trumpp 2006; Cosgrove et al. 2009).”