Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
By Jussi Taipale, James K. Chen, M. K. Cooper, Baolin Wang, R. K. Mann, Ljiljana Milenkovic, M. Scott, P. Beachy. Nature, 2000
1,372 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/85d8eb7cf5064b541c8b824a7036410e9c1835ff
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- P. Beachy
- Jussi Taipale
- E. Epstein
- David M. Berman
- S. S. Karhadkar
- Andrew P. McMahon
- R. Nusse
- Lawrence T. Reiter
In Molecular Biology
- P. Beachy
- Jussi Taipale
- R. Nusse
- Markku Varjosalo
- P. Ingham
- Andrew P. McMahon
- David M. Berman
- E. Epstein
Citations in the corpus
- Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface (2003, background): “This palmitoylated form is then the active species, blocked in its activity by the absence of Rasp.”
- Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis (2003, background): “Cyclopamine, a steroidal alkaloid that inhibits Hh signalling through direct interaction with Sm”
- Drosophila orthologues to human disease genes: an update on progress. (2008, background): “Cyclopamine, a compound in the corn lily, Veratrum californicum, was found to act as an inhibitor of smoothened and, as a consequence, suppressor of hedgehog signaling (81, 82).”
- Communicating with Hedgehogs (2005, background): “Activating mutations of SMO, including some that are associated with human cancers, map to regions of the transmembrane helices that are crucial for all 7TM receptor”
- BMP‐2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop (2003, methodology): “For this purpose, we assessed the effect of Noggin, a well-characterized selective BMP inhibitor,((36)) and cyclopamine, which inhibits Shh signaling,((37)) on Wnt3a-induced ALP expression in C3H10T1/2 cells.”
- Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Hh ligands bind to patched homolog 1 (PTCH1) and PTCH2, which function to inhibit the activity of Smoothened (Smo) in the absence of ligand binding (193, 194).”
- Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours (2003, background): “Autonomous pathway activity was confirmed by the high level of luciferase activity produced by an exogenously introduced Hh-inducible GLI–luciferase reporte”
- Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways (2011, background): “Preclinical agents targeting the Hh pathway Cyclopamine (11-deoxojervine), the prototype of Hh pathway-specific inhibitors, is a plant-derived steroidal alkaloid that binds to and deactivates Smo”
- Patched acts catalytically to suppress the activity of Smoothened (2002, background): “Several lines of evidence indicate that Smo exists in a balance between active and inactive state”
- Hedgehog: functions and mechanisms. (2008, background): “As the Hh pathway in BCC and medulloblastoma is often affected at the level of Ptc or Smo, small molecule antagonists should act at/or downstream from these components (Taipale et al. 2000).”