Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

By N. Takebe, P J Harris, Ronald Q. Warren, S. Ivy. Nature Reviews Clinical Oncology, 2011

1,000 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/01a481d9106140bfbdf8baaf6d5eae25e3fed433

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. E. Batlle
2. V. Plaks
3. Zena Werb
4. J. Massagué
5. Thordur Oskarsson
6. Niwen Kong
7. R. Weinberg
8. A. Moustakas

In Oncology

1. Zena Werb
2. V. Plaks
3. Niwen Kong
4. J. Massagué
5. E. Batlle
6. Thordur Oskarsson
7. R. Weinberg
8. Pengfei Lu

Citations in the corpus

• Metastatic Stem Cells: Sources, Niches, and Vital Pathways (2014, background): “This milieu is thought to support the survival and fitness of CSCs (Takebe et al., 2011) and may select for traits that are advantageous to cancer cells not only locally but also in distant tissues.”
• The Cancer Stem Cell Niche: How Essential is the Niche in Regulating Stemness of Tumor Cells? (2015, positive): “This site is rich with blood vessels as well as niche cells and factors that support the survival and fitness of CSCs (Joyce and Pollard, 2009; Takebe et al., 2011) (Figure 2).”
• Targeting cancer stem cell pathways for cancer therapy (2020, background): “255 Hh signaling also promotes self-renewal and metastasis of CSCs by upregulating the expression of related downstream markers of CSCs, such as Bmi-1, Wnt2, ALDH1, CD44, CCND1, Twist1, C-MYC, Nanog, Oct4, PDGFRα (platelet-derived factor receptor-α), Snail, Jagged 1, and C-MET. 231, 247, [256] [257]”