Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

By S. Thayer, M. Magliano, P. Heiser, Corinne M. Nielsen, D. Roberts, G. Lauwers, Y. Qi, Stephan Gysin, C. Castillo, V. Yajnik and 4 more. Nature, 2003

1,540 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/38b96e94c548f253b3e3e9986bd1c009833e1993

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Hans Clevers
2. R. DePinho
3. N. Bardeesy
4. A. Gregorieff
5. Alec C. Kimmelman
6. K. Frese
7. D. Tuveson
8. A. Maitra

In Oncology

1. D. Tuveson
2. K. Frese
3. Hans Clevers
4. Alec C. Kimmelman
5. A. Rustgi
6. R. DePinho
7. N. Bardeesy
8. K. Strebhardt

Citations in the corpus

• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “Blocking SHH signaling with the inhibitor cyclopamine causes human PDAC cells to undergo apoptosis in vitro and lose tumorigenicity in xenograft assays (Thayer et al. 2003).”
• Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “Both proteins have been implicated in the growth of upper-digestive tract tumors (Berman et al. 2003; Thayer et al. 2003).”
• Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. (2007, background): “1A); mostly, this data confirmed previous observations from our and other groups about the variability of in vitro responses to cyclopamine in pancreatic cancer cell lines (5, 6).”
• Targeting cancer stem cell pathways for cancer therapy (2020, background): “[596] [597] [598] Activation of Hh signaling in CSCs contributes to CSC stemness, chemoresistance, and metastatic dissemination.”
• Stromal biology and therapy in pancreatic cancer (2010, background): “Binding of SHH ligands to the patched1 receptor relieves repression of the 12-transmembrane domain protein Smoothened (SMO), resulting in activation of the Gli family of transcription factors. SHH is overexpressed in neoplastic cells of human pancreatic tumours”
• Hedgehog: functions and mechanisms. (2008, neutral): “Pancreatic cancer (Thayer et al. 2003)”