Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
By David Berman, S. S. Karhadkar, A. Maitra, R. M. D. Oca, M. Gerstenblith, K. Briggs, Antony R. Parker, Y. Shimada, James R. Eshleman, D. N. Watkins and 1 more. Nature, 2003
1,318 citations recorded by the source corpus.
Subfields: Molecular Biology, Oral Surgery, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/c754901d14215384adfda00aa950b595c935ac25
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In Molecular Biology
- Hans Clevers
- R. DePinho
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- S. Angers
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- D. Tuveson
In Pathology and Forensic Medicine
Citations in the corpus
- Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “SHH is normally absent from the pancreas throughout development and adult life but is expressed in PanINs and PDAC, with expression levels that correlate with the grade of the lesion (Berman et al. 2003; Thayer et al. 2003).”
- Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. (2005, background): “CANCER CELL : MAY 2005 the Hedgehog ligand family, has recently been described in both preinvasive and invasive human PDA and suggested as a novel therapeutic target (Berman et al., 2003; Thayer et al., 2003).”
- Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. (2007, background): “1A); mostly, this data confirmed previous observations from our and other groups about the variability of in vitro responses to cyclopamine in pancreatic cancer cell lines (5, 6).”
- Gli proteins in development and disease. (2011, background): “Although early studies suggested that epithelial tumors such as pancreatic cancer secrete and respond to Hh ligand in an autocrinejuxtacrine manner (Berman et al. 2003), Yauch et al. (2008) showed that Hh ligands fail to activate signaling in tumor epithelial cells but promote signaling in the…”
- Wnt signaling in the intestinal epithelium: from endoderm to cancer. (2005, background): “Both proteins have been implicated in the growth of upper-digestive tract tumors (Berman et al. 2003; Thayer et al. 2003).”