Dietary Polyphenols and Their Biological Significance
By Xiuzhen Han, Tao Shen, H. Lou. International Journal of Molecular Sciences, 2007
1,148 citations recorded by the source corpus.
Dietary polyphenols represent a wide variety of compounds that occur in fruits, vegetables, wine, tea, extra virgin olive oil, chocolate and other cocoa products. They are mostly derivatives and/or isomers of flavones, isoflavones, flavonols, catechins and phenolic acids, and possess diverse biological properties such as antioxidant, antiapoptosis, anti-aging, anticarcinogen, anti-inflammation, anti-atherosclerosis, cardiovascular protection, improvement of the endothelial function, as well as inhibition of angiogenesis and cell proliferation activity. Most of these biological actions have been attributed to their intrinsic reducing capabilities. They may also offer indirect protection by activating endogenous defense systems and by modulating cellular signaling processes such as nuclear factor-kappa B (NF-κB) activation, activator protein-1(AP-1) DNA binding, glutathione biosynthesis, phosphoinositide 3 (PI3)-kinase/protein kinase B (Akt) pathway, mitogen-activated protein kinase (MAPK) proteins [extracellular signal-regulated protein kinase (ERK), c-jun N-terminal kinase (JNK) and P38 ] activation, and the translocation into the nucleus of nuclear factor erythroid 2 related factor 2 (Nrf2). This paper covers the most recent literature on the subject, and describes the biological mechanisms of action and protective effects of dietary polyphenols.
Subfields: Biochemistry, Molecular Biology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/48e225962628e4bb9c5a947f67f72d15193eda08
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Citations in the corpus
- Endothelial dysfunction - a major mediator of diabetic vascular disease. (2013, background): “Resveratrol benefits the circulatory system by eliciting a decrease in the oxidation of LDL; by fostering decreases in platelet aggregation; and by promoting relaxation of arterioles [213].”
- Polyphenols in Monogastric Nutrition – A Review (2017, background): “Polyphenols are characterized by low bioavailability and urinary excretion ranges from 0.3% for anthocyanins to 43% for isoflavones such as daidzein found in soybeans (Han et al., 2007; Landete, 2013).”
- Natural Phenolic Compounds From Medicinal Herbs and Dietary Plants: Potential Use for Cancer Prevention (2009, background): “, clove and cinnamon) contain high levels of proanthocyanidins or ellagitannins (21,28).”