A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

By N. Perron, Julia L Brumaghim. Cell Biochemistry and Biophysics, 2009

1,282 citations recorded by the source corpus.

Subfields: Biochemistry, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/20da38d44fbac2b9684197bb7577c030c42e2d14

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. J. Dai
2. M. Valko
3. R. Mumper
4. K. Jomová

In Organic Chemistry

1. K. Jomová
2. J. Dai
3. M. Valko
4. R. Mumper

Citations in the corpus

• Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties (2010, positive): “Phenolic compounds with catecholate and gallate groups can inhibit metal-induced oxygen radical formation either by coordination with Fe and enhancing autoxidation of Fe (as shown in reaction 4 below), or the formation of inactive complex with Cu, Fe, or Cu with relatively weaker interaction [143, 1”
• Rice phenolics efflux transporter 2 (PEZ2) plays an important role in solubilizing apoplasmic iron (2011, background): “PCA and other phenolics serve as allelochemicals, antioxidants, free radical scavengers and inhibitors of nitric-oxide synthase, cyclooxygenase and lipoxygenase, as well as precursors of lignin for microorganisms and plants in various biological systems (Rios et al. 2009; Perron and Brumaghim 2009; ”
• Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, neutral): “…lack of free transition metals in cells, but may play a role in oxidative damage after ischemia-reperfusion or under other oxidative stress conditions that involve accumulation of high levels of intracellular hydrogen peroxide and liberation of Fe 2 + from intracellular storage sites (115, 288).”
• Advances in metal-induced oxidative stress and human disease. (2011, background): “Catechol (contains two hydroxyl groups) and gallol (contains three hydroxyl groups) and the many functionalized derivatives including the majority of polyphenol compounds are effective metal chelators (Perron and Brumaghim, 2009).”
• Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions (2018, background): “These effects are modulated via multiple routes, including nuclear factor-kappaB (NF-κB)- and mitogen-activated protein kinasedependent pathways, and through prevention of the generation of reactive oxygen species by binding iron (70).”