Bioavailability of the Polyphenols: Status and Controversies

By M. D’Archivio, C. Filesi, R. Varì, B. Scazzocchio, R. Masella. International Journal of Molecular Sciences, 2010

846 citations recorded by the source corpus.

The current interest in polyphenols has been driven primarily by epidemiological studies. However, to establish conclusive evidence for the effectiveness of dietary polyphenols in disease prevention, it is useful to better define the bioavailability of the polyphenols, so that their biological activity can be evaluated. The bioavailability appears to differ greatly among the various phenolic compounds, and the most abundant ones in our diet are not necessarily those that have the best bioavailability profile. In the present review, we focus on the factors influencing the bioavailability of the polyphenols. Moreover, a critical overview on the difficulties and the controversies of the studies on the bioavailability is discussed.

Subfields: Biochemistry, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/e61c305d5cac50c7437b610a28d7b274843658ce

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In Biochemistry

1. Y. Freile-Pelegrín
2. D. Robledo
3. Huabin Li
4. F. Deng
5. Yan Tian

Citations in the corpus

• Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties (2015, background): “An exception is green tea catechins, whose aglycones constitute a significant proportion of the total amount in plasma, as they are nonglycosylated flavonoids in food and are readily absorbed at the small intestine without extra modifications [12].”
• Resources and Biological Activities of Natural Polyphenols (2014, background): “On the other hand, because of the hydrolysis of complex phenols, an increase in hydroxytyrosol and tyrosol contents during storage was reported [36].”
• Phenolic Compounds in Brassica Vegetables (2010, background): “Therefore, research is needed on the bioavailability of phenolics to allow us to correlate phenolic intake with one or several accurate measures of bioavailability (such as concentrations of key bioactive metabolites in plasma and tissues) and with potential health effects in epidemiological studies”
• Bioactive phenolic compounds from algae. (2013, background): “Questions concerning the relationship between health benefits and polyphenols generally revolve around bioavailability (d’Archivio et al. 2010).”
• Phenolic Compounds in Honey and Their Associated Health Benefits: A Review (2018, background): “There is no explanation of the process of absorption, metabolism and excretion that is valid for all phenolic compounds [32].”