MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

By Changsheng Du, Chang Liu, Jiuhong Kang, Gui-xian Zhao, Z. Ye, Shichao Huang, Zhenxin Li, Zhiying Wu, G. Pei. Nature Immunology, 2009

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MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development (2010, background): “Recently, inhibition of miR-326 via a miRNA ‘‘sponge’’ was shown to reduce EAE symptoms by preventing Th17 cell differentiation also through a T cell-intrinsic mechanism (Du et al., 2009).”
MicroRNA sponges: progress and possibilities. (2010, background): “Du et al. used a lentiviral miR-326 sponge with tropism for CD4+ T-cells and delivered it to the blood system by a tailvein injection of mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis.”
microRNA regulation of inflammatory responses. (2012, background): “Another promoter of Th17 responses is miR-326 (52).”
MicroRNAs in Common Human Diseases (2012, background): “Immune-related diseases Multiple sclerosis miR-145, miR-34a, miR-155, miR-326 [80,81] Systemic lupus erythematosus miR-146a [82,83] Type II diabetes miR-144, miR-146a, miR-150, miR-182, miR-103, miR-107 [84] Nonalcoholic fatty liver disease miR-200a, miR-200b, miR-429, miR-122, miR-451, miR-27 [86] ”
MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. (2009, background): “TH-17 differentiation (Du et al. 2009).”