Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

By Christopher K. Glass, Kaoru Saijo. Nature reviews. Immunology, 2010

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Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review (2014, background): “In these cells, PPARg does not only regulate genes related to lipid metabolism, but also immunity and inflammation related genes [55–58].”
Alternative activation of macrophages: mechanism and functions. (2010, background): “…the early observation by Glass and colleagues that PPAR gamma is strongly induced by IL-4, PPARs have been investigated in relation to lipid metabolism, macrophage polarization, obesity and insulin resistance, and atherogenesis (reviewed by Glass [Glass and Saijo, 2010] and Chawla [Chawla, 2010]).”
The immune system in atherosclerosis (2011, background): “These events probably affect atherogenesis; several excellent reviews have provided details on these processe”
Macrophage-mediated inflammation in metabolic disease (2011, background): “Several laboratories have reported that the activation of PPARγ and PPARδ attenuates the expression of pro-inflammatory genes in macrophages, thus implicating PPARs in the negative regulation of classical macrophage activatio”
Astrocyte crosstalk in CNS inflammation (2020, background): “Astrocytes, microglia, and their interactions control CNS physiology in health and disease (Colombo and Farina, 2016; Glass and Saijo, 2010; Goldmann and Prinz, 2013; Keren-Shaul et al., 2017; Liddelow and Barres, 2017; Prinz et al., 2019; Rothhammer et al., 2018; Rothhammer and Quintana, 2019; Sofr”