B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

By T. Barr, Ping Shen, S. Brown, Vicky Lampropoulou, T. Roch, Sarah Lawrie, Boli Fan, R. O’Connor, Stephen Anderton, A. Bar-Or and 2 more. Journal of Experimental Medicine, 2012

634 citations recorded by the source corpus.

IL-6–producing B cells contribute to EAE pathology and possibly human MS, whereas ablation of B cell IL-6 is associated with a reduced Th17 response.

Subfields: Immunology, Pathology and Forensic Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/fc4b0a3a977b111a82a85ab4b0feb3f445995955

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1. X. Yao
2. N. Shen
3. Jiaqi Huang
4. M. Fung
5. Yihong Yao
6. R. Faggioni
7. Haihong Zhong

Citations in the corpus

• Targeting interleukin-6 in inflammatory autoimmune diseases and cancers. (2014, result): “, 2012), and another study demonstrated that IL-6 produced by B cells plays a pathogenic role in the development of EAE by promoting Th17 cell differentiation (Barr et al., 2012).”