Variation in the reversibility of evolution

By Henrique Teotónio, Michael R. Rose. Nature, 2000

4,421 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Genetics

View Paper: https://www.semanticscholar.org/paper/7cb16df97d31bb883987221e421993ffed349734

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Ecology, Evolution, Behavior and Systematics

1. V. Narry Kim
2. John J. Rossi
3. Thomas Tuschl
4. David P. Bartel
5. Phillip A. Sharp
6. Olivier Voinnet
7. Young‐Kook Kim
8. T. Rana

In Genetics

1. Jennifer A. Doudna
2. Scott M. Hammond
3. David P. Bartel
4. Phillip D. Zamore
5. Gregory J. Hannon
6. M. Kay
7. Daniel G. Anderson
8. Robert Langer

Citations in the corpus

• RNA Interference: Biology, Mechanism, and Applications (2003, background): “During the occurrence of RNAi/PTGS, double-stranded RNA (dsRNA) molecules, which cleave the inducer molecules into smaller pieces first (16) and eventually destroy the cellular or viral cognate mRNA molecules (called the target) (17) act as inducers or activators of this process.”
• MicroRNA genes are transcribed by RNA polymerase II (2004, background): “Pre-miRNA is subsequently cleaved by cytoplasmic RNase III Dicer (Bernstein et al, 2001; Grishok et al, 2001; Hutvagner et al, 2001; Ketting et al, 2001; Knight and Bass, 2001) into B22-nt miRNA duplex.”
• Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain (2004, background): “RNA silencing is initiated through Dicer-mediated processing of double-stranded RNA into small interfering RNA (siRNA”
• Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway (2004, background): “The same activity is also involved in the generation of short interfering RNAs (siRNA), widely used to experimentally degrade RNA target”
• Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells (2001, background): “The mediators of sequence-specific messenger RNA degradation are 21- and 22-nucleotide small interfering RNAs (siRNAs) generated by ribonuclease III cleavage from longer dsRNA”
• Breaking down the barriers: siRNA delivery and endosome escape (2010, background): “These siRNAs have a characteristic 19-nt duplexed region with 5 -terminal phosphate groups and 2-nt 3 overhangs (Bernstein et al., 2001; Zamore et al., 2000).”
• Induction and suppression of RNA silencing: insights from viral infections (2005, background): “Although RNA silencing operates through diverse pathways, it invariably relies on a set of core reactions that are triggered by dsRNA, which is processed into RNA duplexes that are 21 bp–24 bp in length by the RNaseIII enzyme Dicer and its homologue”
• ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase. (2002, background): “Removing the transgene diverse organisms is triggered by double-stranded repeats from ros1 mutant plants regains the expression RNAs (DsRNAs) (Zamore, 2002; Matzke et al., 2001). of the homologous endogenous gene, suggesting that DsRNAs are cleaved into small sense and antisense smRNAs produced by t”
• Computational and experimental identification of C. elegans microRNAs. (2003, background): “elegans) to release the ~22 nt mature miRNAs (Bernstein et al., 2001; Grishok et al., 2001; Hutvagner et al., 2001; Ketting et al., 2001).”
• A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. (2002, methodology): “…et al. 2001), which initiates RNAi by processing dsRNA silencing triggers into siRNAs, and also processes miRNA precursors into mature miRNAs (Bernstein et al. 2001; Grishok et al. 2001; Hutvagner et al. 2001; Ketting et al. 2001); therefore, we considered the possibility that dFMR1 might…”