RNA Interference: Biology, Mechanism, and Applications

By Neema Agrawal, P. V. Dasaradhi, A. Mohmmed, P. Malhotra, R. Bhatnagar, S. Mukherjee. Microbiology and Molecular Biology Reviews, 2003

1,267 citations recorded by the source corpus.

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RNAi-Based Insecticidal Crops: Potential Effects on Nontarget Species (2013, methodology): “Indeed, the risk of immunostimulation by dsRNAs may be one reason for which the enzyme RNA-dependent RNA polymerase (RdRP), which is responsible for amplifying the abundance of siRNAs in some organisms, has yet to be found in mammals and insects (Agrawal et al. 2003, Dillin 2003).”
Proteolysis Targeting Chimeras as Therapeutics and Tools for Biological Discovery (2020, positive): “The use of RNA interference has become ubiquitous in modern biological research and represents an excellent tool to study protein function (Agrawal et al., 2003; Setten et al., 2019).”
RNAi-mediated chromatin silencing in fission yeast. (2008, background): “In many organisms the expression of a synthetic dsRNA homologous to an endogenous gene can target homologous RNA resulting in degradation of that RNA and in some cases modification of DNA/chromatin at the homologous locus (Agrawal et al. 2003; Hannon 2002).”
Seed-borne plant virus diseases (2013, background): “RNAi-related events were understood in almost all eukaryotic organisms (Agarwal et al. 2003).”