Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway

By Peng Jin, D. Zarnescu, S. Ceman, Mika Nakamoto, J. Mowrey, T. Jongens, D. Nelson, K. Moses, S. Warren. Nature Neuroscience, 2004

645 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/95f924e81fcc8f28fac391ef3d64d6f7f32d04db

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Citations in the corpus

Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. (2010, neutral): “…the RNA interference silencing complex (RISC) and with miRNAs, but FMRP itself is not essential for RNAi-mediated mRNA cleavage (Bolduc et al., 2008; Caudy et al., 2002; Cheever and Ceman, 2009; Hock et al., 2007; Ishizuka et al., 2002; Jin et al., 2004b; Okamura et al., 2004; Plante et al., 2006).”
Drosophila, the golden bug, emerges as a tool for human genetics (2005, background): “This led to the demonstration that a reduction in these components, such as Argonaute (AGO1), is essential for the function of FMR1: reduction in AGO1 levels could suppress the apoptosis phenotype caused by Fmr1 overexpression and could enhance in a dominant manner the phenotype of Fmr1 loss-of-”
The neuronal microRNA system (2006, background): “Several RNA binding proteins that are present in neurons are good candidates for the delivery of mRNAs to cellular destinations and at least one of these proteins, FMRP, is associated with miRNAs and could utilize this association to implement its known function as a translational inhibito”
X-linked mental retardation (2005, background): “There is now evidence that FMRP mediates translational silencing of mRNAs through interaction with microRNAs and the RNA-INDUCED SILENCING COMPLEX (RISC”
Human MicroRNA Targets (2004, background): “Independently, FMRP has been shown to be associated with RISC components and miRNAs (Jin et al. 2004).”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “melanogaster , which showed that the regulation of synaptic plasticity by dFMR, a homologue of FMRP, is partially dependent on dAGO1 (Ref”
Mechanisms of gene silencing by double-stranded RNA (2004, background): “In human biochemical systems, interactions of AGO2/eIF2C2 (eukaryotic translation initiation factor 2C2) with FMRP (fragile X mental retardation protein) — the human homologue of dFXR — has also been observe”
A mammalian microRNA expression atlas based on small RNA library sequencing. (2007, background): “…of Fragile X mental retardation protein (FMRP), which was shown to interact with DICER and AGO protein in the miRNA pathway (Caudy et al., 2002; Jin et al., 2004; Plante et al., 2006), the miRNA profile of the whole brain of 4-day-old FMRP knockout mice and homozygous wild-type littermate were…”
TransmiR: a transcription factor–microRNA regulation database (2009, background): “This binding results in cleavage or translation inhibition of the target mRNAs (1–3). miRNAs play critical roles in many essential biological processes, such as proliferation (4,5), metabolism (6,7), diﬀerentiation (8), development (9,10), apoptosis (7,11,12) and cellular signaling (13).”