arrow encodes an LDL-receptor-related protein essential for Wingless signalling

By M. Wehrli, S. Dougan, K. Caldwell, L. O'Keefe, S. Schwartz, D. Vaizel-Ohayon, E. Schejter, A. Tomlinson, S. DiNardo. Nature, 2000

942 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7afda798f2024b3e1bc91e25789e7185253f0985

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. Fanxin Long
5. P. Beachy
6. K. Willert
7. Jussi Taipale
8. A. Gregorieff

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. Xi He
5. Fanxin Long
6. P. Beachy
7. K. Willert
8. Jussi Taipale

Citations in the corpus

• Reaching a genetic and molecular understanding of skeletal development. (2002, neutral): “Development 126, 3795–3809.signaling via MAPK/ERK-mediated phosphorylation and Arai, F., Miyamoto, T., Ohneda, O., Inada, T., Sudo, T., Brasel, K.,recruitment of p300/CBP (Weilbaecher et al., 2001).”
• The art and design of genetic screens: Drosophila melanogaster (2002, positive): “…the Wg pathway that give a clear SEGMENT-POLARITY phenotype in homozygous mutant embryos are wg itself, arrow ( arr ), armadillo ( arm ; also known as β -catenin) and pangolin ( pan ; also known as TCF / LEF1 ),which interact to form the transcriptional activator at the end of the pathway 23–26 .”
• The Wnt signaling pathway in development and disease. (2004, background): “Fz Down Inactivate Wnt (Muller et al. 1999) Dfz2 Down Inactivate Wnt (Cadigan et al. 1998) Dfz3 Up Activate Wnt (Sato et al. 1999) Fz7 Up Wnt (Willert et al. 2002) Arrow/LRP Down Inactivate Wnt (Wehrli et al. 2000) Dally (HSPG) Down Wnt (Baeg et al. 2001) Wingful/notum Up Inactivate HSPG?”
• Wnt/β-catenin signaling and disease. (2012, positive): “Fzs cooperate with a single-pass transmembrane molecule of the LRP family known as Arrow in Drosophila (Wehrli et al., 2000) and LRP5 and -6 in vertebrates (Pinson et al.”
• Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance (2005, background): “as well as to proteins of the low-density lipoprotein receptor–related protein family, LRP5 and LRP6 (refs”
• Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, background): “As LRP6 is a Wnt coreceptor which acts specifically in the canonical Wnt pathway (Wehrli et al., 2000), it appears that Wnt-5a signals predominantly through a noncanonical Wnt pathway during mouse limb development.”
• E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer (2009, background): “Of utmost importance is the interaction of GSK3β, APC, and axin with β-catenin [78, 79].”
• Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. (2001, background): “…quick interaction between LRP-5 and Axin. the involvement of LRP-6 and its Drosophila homolog Arrow in the canonical Wnt signaling pathway in Drosophila, Xenopus, and mice (Pinson et al., 2000; TamaiThe Interaction of LRP-5 with Axin Is Required for Its Activity et al., 2000; Wehrli et al., 2000).”
• LDL-receptor-related protein 6 is a receptor for Dickkopf proteins (2001, background): “LDL-receptor-related protein 6 (LRP6) is required during Wnt/β-catenin signalling in Drosophila , Xenopus and mouse, possibly acting as a co-receptor for Wn”
• Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility. (2003, background): “LRP, traditionally considered as a receptor involved in hepatic clearance of numerous proteins via endocytosis, has recently been recognized as an important component of cell-cell signaling via the Wnt pathway (32).”
• Wnts and TGFβ in synaptogenesis: old friends signalling at new places (2003, background): “Wnt signal transduction requires the intracellular regions of both LRPs and Fz, and LRP6 in Xenopus has been shown to bind directly to the extracellular domain of Fz, and also to the Wnt”
• Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. (2002, background): “In the case of the Frizzled family of seven-TM receptors, which are closely related to Smo in structure, receptor activation involves the binding of Wnt ligands to the Frizzled CRD (Bhanot et al. 1996) and recruitment of an LDL receptor-related protein (Pinson et al. 2000; Wehrli et al. 2000).”