Wnt/β-catenin signaling and disease.

By Hans Clevers, R. Nusse. Cell, 2012

5,210 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8a94379881b838bc934c06193902633affc1b356

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In Molecular Biology

Citations in the corpus

Small-molecule inhibitors of carboxylesterase Notum (2021, neutral): “Comparison of Notum inhibitors LP-922056 (5), ABC99 (9) and ARUK3001185 (17). Notum–inhibitor structure (PDB) N N S CO2H S Cl Cl N N N O O O N O O Chemical structure not yet disclosed LP-922056 (5) ABC99 (9) ARUK3001185 (17) Yes (6T2K) ND Yes (ND) Notum inhibition OPTS, IC50, nM 1.1 170† ,‡ ,§ 6.5 T”
Endocytosis, Signaling, and Beyond (2014, background): “On Wnt signaling, cytosolic b-catenin is instead stabilized and translocates to the nucleus to activate specific transcriptional programs (Moon 2005; Clevers and Nusse 2012).”
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis (2013, positive): “As ﬁrst demonstrated for intestinal crypts (Korinek et al , 1998), Wnt signalling plays a crucial role in the regulation of multiple types of adult stem cells and progenitors (Clevers and Nusse, 2012).”
Wnt/ b -Catenin Signaling, Disease, and Emerging Therapeutic Modalities (2017, background): “In this review, we will present an update (Clevers and Nusse, 2012) on recent insights into Wnt signaling in various contexts, during normal physiology as well as in disease.”
Notum is required for neural and head induction via Wnt deacylation, oxidation and inactivation (2015, positive): “TheWnt family of secreted lipoproteins controls animal development including axial patterning and cell fate specification and governs tissue homeostasis and stem cell renewal (Clevers and Nusse, 2012; MacDonald et al., 2009).”
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974 (2013, background): “Elevated levels of β-catenin ultimately lead to its translocation into the nucleus to form a complex with LEF/TCF and drive downstream gene expression (3).”
TFEB at a glance (2016, background): “Finally, MiT-mediated upregulation of the endo-lysosomal system induces the activation of tumorigenic signaling pathways, such as Wnt signaling, with established roles in the initiation and progression of many types of cancer (Clevers and Nusse, 2012; Marchand et al., 2015; Ploper et al., 2015).”
Targeting cancer stem cell pathways for cancer therapy (2020, background): “Stem cell signaling pathways and transcriptional circuits are related to the alteration or reactivation of signaling pathways.(144) Tumor dormancy is a lag phenomenon in tumor growth.”
Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “These two pathways are both involved in the onset and development of the OA.(141,166) Wnt 5a and Wnt11 are the two ligands that are associated with the non-canonical pathway, and they are both detected in the human OA cartilage.”
The intestinal crypt, a prototype stem cell compartment. (2013, background): “For a detailed overview of the Wnt pathway, the reader is referred elsewhere (Clevers and Nusse, 2012).”