LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

By B. Mao, Wei Wu, Yan Li, Dana Hoppe, P. Stannek, A. Glinka, Christof Niehrs. Nature, 2001

1,106 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f2069258ee240846ff9997f1d1c816b48342cdb0

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Citations in the corpus

The Wnt signaling pathway in development and disease. (2004, background): “Because LRP can interact with the cytosolic protein Axin (Mao et al. 2001b, Tolwinski et al. 2003) (Figures 2 and 3), Wnts are thought to induce the phosphorylation of LRP on a PPP(S/T)P motif, thus allowing the docking of Axin to the LRP cytoplasmic tail.”
Secreted and transmembrane wnt inhibitors and activators. (2013, background): “Within LRP6, the last two YWTD–epidermal growth factor (EGF) repeat domains mediate binding to Dkk1 (Mao et al. 2001).”
Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling (2002, background): “Dkk1 has been shown to inhibit Wnt signalling by binding to and antagonizing LRP5/”
Global gene profiling in human endometrium during the window of implantation. (2002, background): “Dickkopf-1 inhibits Wnt signaling by binding LRP5/6 (40), and FrHPE inhibits Wnt action by competitive binding to Wnt ligand(s).”
Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. (2003, methodology): “For in situ hybridization, Dkk1 antisense riboprobe was synthesized from the mouse cDNA (a kind gift from C. Niehrs, DKFZ, Heidelberg, Germany), and the procedure was performed as described (Moorman et al. 2001).”
Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “Dkk1 binds both Lrp5 and Lrp6, but does not interact with other members of the LDLR family such as LDLR, VLDLR, ApoER2 or LRP (Semenov et al., 2001; Mao et al., 2001a).”
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer (2021, background): “of this notion, DKK proteins were reported to negatively affect the surface expression of Kremen, and DKK3 was shown to inhibit Wnt signaling by triggering LRP5/6 internalization through the formation of a ternary complex with Kremen1/2 receptors.(191,192,277) In contrast, Ferrari et al.”
Signalling in neural development: WNTS in the vertebrate nervous system: from patterning to neuronal connectivity (2005, neutral): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=13380">DKK1 ), a secreted WNT antagonis”