Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

By A. Duncan, F. Rattis, L. Dimascio, Kendra L Congdon, Gregory Pazianos, Chen Zhao, K. Yoon, J. Cook, K. Willert, N. Gaiano and 1 more. Nature Immunology, 2005

868 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5cd11c66102fc4bd3b797c9f8483a44c8451985d

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Citations in the corpus

Rbm15 Modulates Notch-Induced Transcriptional Activation and Affects Myeloid Differentiation (2007, background): “Several studies show that Notch facilitates bone marrow stem cell expansion and plays a role in the stem cell niche in vivo ( 11 ).”
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. (2007, background): “This suggests that intracellular ROS levels and the related signal transduction pathways, together with specific characteristics which define the osteoblastic niche, are responsible for long term self-renewal as well as activation, proliferation, and differentiation of HSCs.”
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (2006, background): “Notch influences the self-renewal of hematopoietic stem cells (HSCs) (Varnum-Finney et al. 2000; Calvi et al. 2003; Duncan et al. 2005), T-cell specification from a multipotent precursor (Pui et al.”
Notch signalling in vertebrate neural development (2006, background): “Crosstalk between Notch and WNT signalling has been documented in somitogenesis, haematopoiesis and tumour formation in the ski”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “…in downstream Notch signal transduction pathways characterize the difference between stem and progenitor cells in the hematopoietic system (Duncan et al. 2005). nIPCs are also present within the VZ, particularly at early time periods, prior to the formation of a distinct SVZ (Noctor et…”
RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus (2010, background): “Notch signaling interacts with a number of other pathways to control stem cell maintenance in the hematopoietic system (Duncan et al., 2005), the embryonic nervous system (Takizawa et al., 2003; Shimizu et al., 2008), and the adult subventricular zone (Andreu-Agullo et al., 2009).”
Mechanisms of asymmetric stem cell division. (2008, background): “Given that Notch signaling is known to be essential for maintaining the undifferentiated state of hematopoietic stem cells (Duncan et al., 2005), those asymmetric cell divisions will probably form one stem cell and one more committed daughter cell.”
Hematopoiesis: an evolving paradigm for stem cell biology. (2008, background): “Stimulation of the Notch pathway also increases HSC activity and appears to be required for the increased self-renewal upon Wnt activation (Duncan et al., 2005).”
Wnt signalling in stem cells and cancer (2005, background): “Additionally, Wnt signalling probably integrates with other niche-derived signals such as BMP, Shh and Notc”
Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation (2008, background): “In transgenic Notch reporter mice that express GFP under the control of repeated RBP-Jκ response element”