The Wnt signaling pathway in development and disease.

By C. Logan, R. Nusse. Annual Review of Cell and Developmental Biology, 2004

5,496 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/76c366859763ace4bbd5d0fbee8f9f094c8dc3d5

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Citations in the corpus

Cysteine‐rich domains related to Frizzled receptors and Hedgehog‐interacting proteins (2012, background): “Wnts and Hedgehogs are secreted morphogenetic proteins that play essential roles in various developmental processes and diseases.(1,2) Wnts are cysteinerich glycoproteins modified with palmitoyl groups.”
Osteoblast-Osteoclast Communication and Bone Homeostasis (2020, background): “The WNT pathway is crucial for the maintenance of bone homeostasis by regulating osteoblastogenesis and osteoclastogenesis through both β-catenin-dependent (canonical) and -independent (noncanonical) pathways [58].”
A human protein-protein interaction network: a resource for annotating the proteome. (2005, neutral): “Eight proteins, e.g., (ZHX1, PTN, EEF1A1, ANP32A, CRMP1, GTF3C1, UNC119, and KIAA1377) were found to connect via HC interactions with proteins in the Wnt signaling pathway (Figure 5B), which controls patterning and organogenesis during development and is important for tumor formation in adults ( Log”
Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction (2005, neutral): “The results suggest that (1) clusters 1 and 2 are both physiologically relevant CK1g phosphorylation sites that activate Wnt signalling, and (2) they require an intact PPPSP motif.”
WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis (2009, background): “stabilization and nuclear localization of this free pool are necessary for b-catenin as a coactivator of TCF-dependent transcription (Clevers, 2006; Klaus and Birchmeier, 2008; Logan and Nusse, 2004; Moon et al., 2004).”
Balancing cell adhesion and Wnt signaling, the key role of β-catenin (2006, background): “In the past two decades, researchers have identified crucial molecular components that control patterning and organogenesis in the embryo and which, when deregulated, modulate tumorigenesis [ 1-4 ].”
The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth (2008, background): “b-catenin is the central effector in the canonical Wnt signaling pathway that controls stem cell maintenance, development and carcinogenesis [20].”
INTERNATIONAL UNION OF BASIC AND CLINICAL PHARMACOLOGY REVIEW WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3 (2014, positive): “tankyrase inhibitors, secreted FZD-related proteins, Rspondin, Dickkopf1 (DKK1), Norrin and molecules targeting the co-receptors of the WNT/FZD pathway are being considered as putative drugs for diseases such as different types of cancer, neurodegenerative diseases and osteoporosis (Logan and Nusse,”
Two βs or not two βs: regulation of asymmetric division by β-catenin (2007, background): “In the canonical Wnt pathway, the destruction complex (Axin, APC, GSK-3b) phosphorylates b-catenin and directs it to ubiquitin-mediated proteolysis [ 9 ].”
Wnt Signaling Requires the Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes (2010, positive): “Sequestration of GSK3 Regulates Protein Half-Life Phosphorylation of b-Catenin or Smad1 by GSK3 causes recognition by E3 polyubiquitin ligases and protein degradation (Logan and Nusse, 2004; Fuentealba et al., 2007).”
Wnt/β-catenin signaling is required for CNS, but not non-CNS, angiogenesis (2009, background): “Stabilized -catenin is then able to translocate to the nucleus and through interactions with the TCF/LEF-1 complexes, regulates the expression of specific genes (7).”
Cdks, cyclins and CKIs: roles beyond cell cycle regulation (2013, background): “However, in the presence of Wnt, the destruction complex is inactivated, and β-catenin accumulates and translocates into the nucleus where it acts as a co-activator for TCF/LEF-mediated transcription (Logan and Nusse, 2004; Niehrs, 2012).”
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context (2006, background): “Wnt signaling controls a variety of adult and developmental processes, largely by modulating gene transcription [1].”
Regulation of osteoblast differentiation by transcription factors (2006, background): “Loss-of-function mutations in Lrp5 result in low bone mass, while gain-of-function mutations in Lrp5 result in high bone mass [Logan and Nusse, 2004].”
Expression profiling of ependymomas unravels localization and tumor grade‐specific tumorigenesis (2009, background): “It is a major controller of cell fate, proliferation, migration, cell polarity, and cell death; and it is implicated in a variety of cancers.(32,33) In the molecular signature of WHO grade 3 ependymomas, we identified high expression of c-MYC, 1 of the Wnt/b-catenin signaling pathway genes.”