Regulation and role of autophagy in mammalian cells.

By A. Meijer, P. Codogno. International Journal of Biochemistry and Cell Biology, 2004

669 citations recorded by the source corpus.

Subfields: Cell Biology, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/e333a895277de31cbe01d34d0969124b791349ea

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. N. Mizushima
2. D. Klionsky
3. Beth Levine
4. A. Cuervo
5. V. Deretic
6. Zhifen Yang
7. I. Slaninová
8. Ralph A. Nixon

In Epidemiology

1. D. Klionsky
2. N. Mizushima
3. Beth Levine
4. V. Deretic
5. A. Cuervo
6. Ralph A. Nixon
7. Zhifen Yang
8. I. Slaninová

In Physiology

1. N. Mizushima
2. D. Klionsky
3. Beth Levine
4. Ralph A. Nixon
5. A. Cuervo
6. P. Codogno
7. V. Deretic
8. T. Yoshimori

Citations in the corpus

• Oxidative Stress and Autophagy (2006, positive): “Interested readers are referred to recent comprehensive reviews in this topic (33, 43, 49, 57, 69, 79).”
• Unveiling the roles of autophagy in innate and adaptive immunity (2007, background): “The classical signalling pathways that regulate autophagy have been reviewed extensively elsewhere 21, 22 , whereas signals of particular relevance to immunity are discussed later.”
• Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease (2005, background): “Autophagosomes mature to single membrane autophagolysosomes (Dunn, 1990b) by fusing with lysosomes or other mature AVs, whereupon they acidify and acquire proteolytic enzymes (Meijer and Codogno, 2004).”
• Subversion of Cellular Autophagosomal Machinery by RNA Viruses (2005, background): “Rapamycin inhibits the function of the mammalian target of rapamycin, a known repressor of the autophagic pathway (reviewed in [14] ).”
• Autophagy and signaling: their role in cell survival and cell death (2005, background): “autophagosomal membrane and also to increase the expression of ATG8, which is involved in the expansion step of the autophagosomal membrane.(8) Further evidence in support of opposing regulatory effects on protein synthesis and auto-”
• Protein turnover via autophagy: implications for metabolism. (2007, background): “Regulation of autophagy has been extensively reviewed (1, 35, 36, 65, 76, 80), and we only briefly highlight this topic here.”
• The mechanisms and roles of selective autophagy in mammals (2022, background): “aMPK activates ulK1 during starvationinduced autophagy, while mTor inhibits ulK1 (ref.(231)).”
• Autophagy is a Protective Mechanism in Normal Cartilage and its Aging-related Loss is Linked with Cell Death and Osteoarthritis (2010, background): “Atg genes control the autophagy process leading to the induction and nucleation of autophagic vesicles as well as to their expansion and fusion with lysosomes, allowing enzymatic degradation and recycling (9,10).”
• Growing roles for the mTOR pathway. (2005, background): “The raptor branch of the mTOR pathway modulates a stunning number of major processes, including mRNA translation (reviewed in [13]), ribosome biogenesis [14], nutrient metabolism [15] and autophagy (reviewed in [16]) (Figure 1).”
• The role of autophagy in cancer development and response to therapy (2005, background): “It is an evolutionarily conserved process that occurs in all eukaryotic cells, from yeast to mammal”
• Eaten alive: a history of macroautophagy (2010, background): “Subsequent studies demonstrated that activation of this pathway, by expressing an active form of PKB, or expressing a constitutively active form of PDK1, has an inhibitory effect on autophag”