Control of mitochondrial morphology by a human mitofusin.

By A. Santel, M. Fuller. Journal of Cell Science, 2001

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Citations in the corpus

Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity (2004, background): “…yeast Fzo1, and the mammalian homologues Mitofusin 1 and 2 (Mfn1 and Mfn2), function in the mitochondrial fusion reaction (Hales and Fuller, 1997; Hermann et al., 1998; Rapaport et al., 1998; Santel and Fuller, 2001; Rojo et al., 2002; Eura et al., 2003; Mozdy and Shaw, 2003; Santel et al., 2003).”
Mitochondrial dynamics and apoptosis. (2008, background): “The GTPase activity of mitofusins is essential for mitochondrial fusion (Hales and Fuller 1997; Hermann et al. 1998; Santel and Fuller 2001).”
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. (2004, background): “, 2003), Mfn2 (Santel and Fuller, 2001; Ishihara et al., 2003), and Opa1 (MGM1 in yeast) (Olichon et al.”
Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis (2002, methodology): “Mfn2-YFP was constructed from the GFP construct described previously (Santel and Fuller, 2001).”
OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. (2006, unknown): “Mitofusin (MFN) -1 and -2 are dynamin-related proteins of the outer membrane (OM) essential for mitochondrial tethering and fusion (Santel and Fuller, 2001; Legros et al., 2002; Santel et al., 2003; Chen et al., 2003).”
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells (2010, unknown): “Opa1 are essential for mitochondrial fusion (Alexander et al., 2000; Delettre et al., 2000; Santel and Fuller, 2001).”
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability (2011, background): “, and mitofusins (MFN) 1 and 2 of the outer membran”
Mitochondrial fusion and fission in mammals. (2006, background): “Mitofusins are conserved, large GTPases localized to the mitochondrial outer membrane (Chen et al. 2003, Rojo et al. 2002, Santel & Fuller 2001).”
Mitochondrial dynamics in mammalian health and disease. (2009, background): “Human MFN1 protein shows 63% of identity with MFN2, and both proteins share the same relevant functional domains (Table 1) (256).”