Tolerance, DCs and tryptophan: much ado about IDO.

By U. Grohmann, Francesca Fallarino, Paolo Puccetti. Trends in immunology, 2003

807 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/78138c4da7a53b7faed764d29dc044f0abb3a81e

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In Behavioral Neuroscience

1. D. Munn
2. A. Mellor
3. C. Garlanda

In Biological Psychiatry

1. D. Munn
2. A. Mellor
3. W. Zou

Citations in the corpus

• Modulation of tryptophan catabolism by regulatory T cells (2003, background): “, which would involve the immunomodulatory properties of the enzyme indoleamine 2,3-dioxygenase (IDO”
• Ido expression by dendritic cells: tolerance and tryptophan catabolism (2004, background): “Each enzyme catalyses the same reaction, oxidative cleavage of the 2,3 double bond in the indole ring, which is the first, rate-limiting step in tryptophan catabolism by the kynurenine pathwa”
• The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006, background): “T he immunoregulatory enzyme IDO mediates conversion of the essential amino acid tryptophan to metabolic byproducts collectively known as kynurenines (1, 2).”
• Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “By depleting tryptophan from local microenvironment, IDO blocks activation of T lymphocytes [83].”
• Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism (2010, background): “IDO is expressed inmonocytes/macrophages or DC in response to LPS or CpG stimulation to modulate inflammatory responses (37, 43).”
• Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes. (2004, background): “In the current study we focus on the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO), an immunosuppressive mechanism shared by several different cell types in the immune system (16, 17).”
• Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies (2019, background): “Instead, IDO is induced by inflammatory stimulus such as 775 LPS or IFN-γ, which has been observed both in mammals (Grohmann et al., 2003) and 776 fish (Cortés et al., 2016).”
• The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance (2008, background): “Immature myeloid cells are expanded in chronic infections and cancer and act as potent suppressors of T-cell dependent anti-tumor immunity via unbalanced inducible nitric oxide synthase (iNOS) and arginase-1 activity (21).”
• Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells (2011, background): “IDO normally has low basal expression but is rapidly induced by interferon-γ (IFN-γ) in dendritic cells (DCs”