Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.

By D. Munn, Madhav Sharma, Deyan Hou, B. Baban, J. Lee, S. Antonia, J. Messina, P. Chandler, P. Koni, A. Mellor. Journal of Clinical Investigation, 2004

908 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Immunology

View Paper: https://www.semanticscholar.org/paper/0da6d0191fdb482ec00d4dbbdb53c1628329e108

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

In Immunology

Citations in the corpus

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase. (2007, methodology): “However, induction of a another suppressive B7 family member, B7-H4, on APCs by Tregs has been recently shown (25).”
Coordinated regulation of myeloid cells by tumours (2012, background): “The accumulation of IDO-expressing DCs (most of which are pDCs) in tumour-bearing mice and in some patients with cance”
Immunosuppressive strategies that are mediated by tumor cells. (2007, background): “Adoptive transfer of these DCs into naive hosts created profound local T-cell anergy (160).”
IDO in the Tumor Microenvironment: Inflammation, Counter-regulation and Tolerance (2016, neutral): “Tumors in this category include melanoma [42-44], colon cancer [45, 46], brain tumors [47], ovarian cancer [48], acute myelogenous leukemia [49, 50], and a number of others [51-53].”
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, background): “upregulated or downregulated in response to external proinflammatory or activated T-cell stimuli (119).”
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells1 (2006, background): “Neither mechanism alone can explain the diversity (3, 5, 6, 8), durability (4), and Ag specificity (10) of the IDO-mediated suppressive effect.”
Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation (2005, background): “Moreover, the phenotype of IMDCs is clearly different from that of indoleamine 2,3-dioxygenase–expressing plasmacytoid DCs that also may exert immunosuppressive functions (33).”
Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4 (2013, background): “…found in primary melanoma and draining lymph nodes (Munn et al., 2004; Polak et al., 2007; Brody et al., 2009), and its presence has been shown to correlate with tumor progression and invasiveness (Munn et al., 2004; Lee et al., 2005; Harlin et al., 2006; Polak et al., 2007; Weinlich et al., 2007).”