Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism
By N. Nguyen, A. Kimura, T. Nakahama, I. Chinen, K. Masuda, K. Nohara, Y. Fujii‐Kuriyama, T. Kishimoto. Proceedings of the National Academy of Sciences of the United States of America, 2010
687 citations recorded by the source corpus.
Subfields: Biological Psychiatry, Immunology
View Paper: https://www.semanticscholar.org/paper/3c95d0b82720ce2c3bb32837a96f6abdb359da38
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In Biological Psychiatry
In Immunology
- M. Narazaki
- Toshio Tanaka
- Cristina Gutiérrez-Vázquez
- F. Quintana
- T. Kishimoto
- Alec C. Kimmelman
- A. Schietinger
- Markus F. Neurath
Citations in the corpus
- Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. (2012, background): “receptor (AHR) as a direct target of kynurenine (10, 21, 22).”
- IL-6 in inflammation, immunity, and disease. (2014, background): “Interestingly, Ahr showed a negative regulatory effect on peritoneal macrophages and bone marrow–derived dendritic cells (BMDC) (Nguyen et al. 2010).”
- Metabolic Interactions in the Tumor Microenvironment (2017, background): “Activation of AHR signaling in CD4+ T cells primes their differentiation into the immunosuppressive T regulatory fate [82] and negatively regulates dendritic cell immunogenicity [83].”
- Tolerogenic dendritic cells (2016, background): “Concomitantly, AhR activation boosts the ability of DCs to promote the differentiation and expansion of FoxP3 Tregs through the production of kynurenins and RA [55, 94, 95].”
- Regulation of the immune response by the aryl hydrocarbon receptor (2018, background): “, 2010), which boosts FoxP3 Treg cell differentiation and suppresses effector T cells (Coombes et al., 2007; Mucida et al., 2007; Nolting et al., 2009; Pino-Lagos et al., 2011; Sun et al., 2007).”