The Yin‐Yang of tumor‐associated macrophages in neoplastic progression and immune surveillance

By P. Allavena, A. Sica, C. Garlanda, A. Mantovani. Immunological Reviews, 2008

643 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/ab8a98307472a2ee4dc56ae63a0768fbc11d59fd

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Citations in the corpus

Macrophages, innate immunity and cancer: balance, tolerance, and diversity. (2010, background): “There is evidence that CC and CXC chemokines [25,26] play a role in MDSC recruitment in tumors.”
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “Finally, inflammatory reactions can also result in antitumor activity (the bright side of the force) [4,94,181].”
Systemic effects of local radiotherapy (2009, positive): “Among the latter, tumorassociated macrophages promote tumor progression by secreting a variety of factors, including matrix metalloproteinases and immunosuppressive cytokines [22].”
Macrophages in Tumor Microenvironments and the Progression of Tumors (2012, background): “Chemokines, such as CCL17 and CCL22, can prevent the infiltration of cytotoxic T-cells but promote that of Treg and Th2 cells [38, 94].”
Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation (2009, background): “and/or tumor cell-derived proteases [24, 40].”
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): The next decade (2013, background): “Tumor-associated macrophages and neutrophils are therefore now discriminated on the basis of markers into antitumoral macrophages (M1) and neutrophils (N1) and antitumoral myeloid cells, respectively M2 and N2 (Allavena et al., 2008; Piccard et al., 2012).”
Polarization of Tumor-Associated Neutrophil (TAN) Phenotype by TGF-β: “N1” versus “N2” TAN (2009, background): “The tumor microenvironment polarizes TAMs toward a protumor (M2) versus an antitumor (M1) phenotype (Allavena et al., 2008).”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Therefore, iNKT and type II NK cells are similar to M1 and M2 (or classically activated and alternatively activated) macrophages (73) in that one population promotes tumor progression while the other population enhances tumor growth by suppressing antitumor immunity.”
Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages (2015, methodology): “We thank the fellowship for LCG (207760), provided by the Consejo Nacional de Ciencia y Tecnología (CONACyT), Mexico, and the FNS (31-46833) and the Ligue Pulmonaire Genevoise.”
Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “M1-type macrophages mainly behave as an antitumor role in the TIME by mediating antibody-dependent cellular cytotoxicity and producing ROS and tumor necrosis factor (TNF) [123], whereas M2-type macrophages exhibit tumor-promoting activity by contributing to the activation of tumor angiogenesis, immu”
The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis (2017, background): “In liver injuries, Kupffer cells secrete anti-inflammatory cytokines such as IL-10, IL-4, and IL-13 [47–49].”