A Hexanucleotide Element Directs MicroRNA Nuclear Import

By Hun-Way Hwang, Erik A. Wentzel, Joshua T. Mendell. Science, 2007

729 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/73c5e5a9068943f4b8ed1a8d56465caf92ab2103

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Citations in the corpus

Many roads to maturity: microRNA biogenesis pathways and their regulation (2009, background): “It has a distinctive hexanucleotide terminal motif, a transferable nuclear localization element; this suggests that, despite their shortness, miRNAs might contain cis -acting regulatory motif”
Human tRNA-derived small RNAs in the global regulation of RNA silencing. (2010, background): “8A), the latter finding being consistent with what had been reported for microRNA levels of subconfluent, serum-starved cells (Hwang et al. 2009).”
Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “This suggests that despite their small size, specific miRNAs contain additional sequence elements that control their behavior, probably through specific recognition by RNA-binding protein cofactors, thereby affecting miRNA turnover (Ambros, 2008; Hwang et al., 2007).”
The widespread regulation of microRNA biogenesis, function and decay (2010, background): “miR-29b decays faster in cycling mammalian cells than in cells arrested in mitosi”
Genetic variation in microRNA networks: the implications for cancer research (2010, neutral): “, nuclear import of miRNAs with distinctive hexanucleotide terminal motif”
Origins and Mechanisms of miRNAs and siRNAs (2009, background): “Even this rule, however, is not absolute; human miR-29b is a nuclear miRNA (Hwang et al., 2007), and Imp8 stimulates nuclear localization of Ago2 in cells (Weinmann et al., 2009).”
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA (2011, background): “…activity has been detected in the nucleus of human cells (Langlois et al, 2005; Robb et al, 2005), and a subset of miRNAs are predominantly nuclear (Hwang et al, 2007; Liao et al, 2010), suggesting that miRNAs may have a variety of biological functions distinct from canonical 30 UTR target mRNA…”
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression (2008, background): “Of note, miR-29a, which is coexpressed as a cluster with miR-29b-1 on chromosome 7 in human (27), was found down-regulated by the microarray experiments but failed to reach a significant value (Dataset S2), perhaps because of the cross-reactivity of the miRNA probes (12).”
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? (2008, background): “Indications that mammalian miRNAs can be imported into the nucleu”