The widespread regulation of microRNA biogenesis, function and decay

By Jacek Krol, Inga Loedige, W. Filipowicz. Nature reviews genetics, 2010

4,719 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8b13c01dd4532e45b9d2a59b874d0c3af3ad2878

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Citations in the corpus

Mechanisms of miRNA-Mediated Gene Regulation from Common Downregulation to mRNA-Specific Upregulation (2014, background): “…have been a subject of significant research work since the discovery of lin-4 in the early 1990s, underscoring the importance of posttranscriptional gene regulation in cis and trans [1]. miRNAs are a subset of endogenously-initiated, single-stranded noncoding RNA guide molecules, traceable in…”
Trained immunity: a program of innate immune memory in health and disease (2016, background): “miRNAs may also contribute to trained immunity (86), mainly because of the reportedly long half-life of these molecules (87) that, combined with the limited proliferative ability of myeloid cells, would result in their persistence after removal of the primary stimulus.”
The functional role of long non-coding RNA in human carcinomas (2011, background): “This class includes the well-documented miRNAs, RNAs ~22 nucleotides (nt) long involved in the specific regulation of both protein-coding, and putatively non-coding genes, by post-transcriptional silencing or infrequently by activation [33-35].”
ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data (2016, background): “The dysregulation of these RNA molecules have been shown to contribute to developmental, physiological and pathological processes (5,7).”
Non-coding RNAs as regulators of embryogenesis (2011, background): “Inhibition of Dicer-mediated pre-let-7 processing depends on LIN28-mediated recruitment of the non-canonical poly(A) polymerase TUTase4 (also known as ZCCHC1), which adds an oligo-uridine tail to the 3′ end of pre-let-7 and causes its degradation (reviewed in Ref”
Non-coding RNAs in human disease (2011, background): “Biogenesis of miRNAs takes place through a multi-step process that involves the RNase III enzymes Drosha and Dicer and ultimately results in the production of mature miRNAs of ~22 n”
The Somatic Genomic Landscape of Glioblastoma (2013, background): “Regulatory Networks of miRNA and mRNA in Gliomagenesis MicroRNAs (miRs) have been found to promote or suppress oncogenesis through modulation of gene expression via mRNA degradation or inhibition of translation (Bartel, 2004; Krol et al., 2010).”
Evolution of microRNA diversity and regulation in animals (2011, background): “1 ; more detailed information can be found elsewhere (for example, reviewed in Ref”
Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling (2011, background): “miRNAs are 19-23 nucleotide (nt) RNAs that regulate gene expression (3, 4, 5).”
Gene silencing by microRNAs: contributions of translational repression and mRNA decay (2011, neutral): “jpg"/> MicroRNAs (miRNAs) are key regulators of gene expression that have important roles in a wide range of biological processes, including animal and plant development, cell proliferation and differentiation, apoptosis and metabolis”