miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA

By T. B. Hansen, E. D. Wiklund, J. Bramsen, Sune B. Villadsen, Aaron L. Statham, Susan J. Clark, Jørgen Kjems. EMBO Journal, 2011

955 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/477d4ec44798ae14061949a4fd967cbee42644ee

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Citations in the corpus

Circular RNA Expression: Its Potential Regulation and Function (2016, background): “The first example is CDR1as, which has two functions: (i) as a trans-regulator of CDR1 mRNA through a mechanism that is regulated by AGO2- and miR-671-mediated cleavage [21]; and (ii) as a miRNA sink for miR-7, thus regulating neural gene expression [4].”
Regulation of circRNA biogenesis (2015, background): “Recently, a handful of circRNAs have been shown to be involved in gene expression regulation as miRNA sponges.(19,21,40,41) Strikingly, some circular intronic RNAs and circRNAs with retained introns were also reported to function as positive regulators of RNA Pol II transcription in the nucleus.”
Metazoan MicroRNAs (2018, background): “…slicing has been reported for only 20 cellular transcripts (Yekta et al., 2004; Davis et al., 2005; Shin et al., 2010), one circular RNA (Hansen et al., 2011), and a few viral mRNAs (Sullivan et al., 2005; Barth et al., 2008), and examples of endogenous miRNA-directed slicing have yet…”
Expanded identification and characterization of mammalian circular RNAs (2014, background): “In an intriguing elaboration of this regulatory pathway, the activity of the mammalian miR-7 miRNA can be inhibited by CDR1as/ciRS-7, which is in turn targeted by another miRNA, miR-671, which shows near-perfect complementarity and triggers endonucleolytic cleavage of CDR1as [8-10].”
CircNet: a database of circular RNAs derived from transcriptome sequencing data (2015, background): “For instance, a circRNA named CDR1as (15) expressed in human and mouse brain was shown to negatively regulate miR-7 in a posttranscriptional manner (12,15,16); this mechanism appears to be evolutionarily conserved (12).”
Detecting circular RNAs: bioinformatic and experimental challenges (2016, background): “Initial rare observations of circular RNA were serendipitous in the context of the in-depth study of a particular gene and, with the exception of SRY 12 and CDR1 antisense RNA ( CDR1as ) 13 , were generally dismissed as anomalies owing to their low abundance ( DLL 14 , ETS‑1 (REF.”
Circular RNAs are abundant, conserved, and associated with ALU repeats. (2013, background): “Additionally, we observed backsplice events that were not enriched by RNase R; for example, the recently reported CDR1 antisense transcript (Hansen et al. 2011).”
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. (2016, background): “Following their biogenesis, circRNAs are released from the nucleus to the cytoplasm (102, 124, 186, 237), by a so far unknown transport mechanism, where they unfold their unique biological function described below.”
DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts (2015, background): “LncBase offers extensive information for each identified interaction, such as gene/miRNA details [4,5], as well as active links to UCSC graphical representation [6], Ensembl, miRBase and DIANA disease tag cloud [8].”
Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway (2015, background): “This striking feature suggested that circular RNA possibly functioned as a miRNA sponge [6, 9, 31].”