Genetic variation in microRNA networks: the implications for cancer research

By Bríd Ryan, A. Robles, C. Harris. Nature Reviews. Cancer, 2010

1,295 citations recorded by the source corpus.

Many studies have highlighted the role that microRNAs have in physiological processes and how their deregulation can lead to cancer. More recently, it has been proposed that the presence of single nucleotide polymorphisms in microRNA genes, their processing machinery and target binding sites affects cancer risk, treatment efficacy and patient prognosis. In reviewing this new field of cancer biology, we describe the methodological approaches of these studies and make recommendations for which strategies will be most informative in the future.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2993200da73c2e1cf4511a24f96095d6f65ac7e2

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Citations in the corpus

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology (2020, background): “…in mature miRNAs or their binding sites could significantly change their targeting abilities and dysregulate the expression of many genes simultaneously, whereas variations in primary or precursor miRNAs could alter the expression levels of mature miRNAs by affecting miRNA processing (48,49).”
miRTarBase update 2022: an informative resource for experimentally validated miRNA–target interactions (2021, background): “Recent studies suggested that instead of being mediated by regulators, miRNA–mRNA binding affinity and miRNA expression are affected by SNPs and variations (57,58).”
MicroRNAs in human cancer. (2013, background): “Single nucleotide polymorphisms (SNPs), located both in precursor and mature miRNA sequences, have been examined in the context of disease risk for various malignancies but have not been validated as causative (reviewed in [75]).”
Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling (2011, background): “miRNA nucleotide variations are being implicated in tumorigenesis; however, evidence for their significance is limited (44).”
MicroRNAs in stress signaling and human disease (2012, background): “Nevertheless, some polymorphic variants within miRNAs have been associated with human disease risk, most notably cancer (Ryan et al., 2010).”
miRNAs in human cancer (2010, background): “Post-transcriptional regulation of miRNAs themselves through RNA editing or terminal modifications was shown to alter miRNA targeting, processing and stability, but connection of these modifications to tumorigenesis has not yet been definitive (reviewed in [47,66,67]).”
Long intergenic non-coding RNAs – New links in cancer progression (2011, background): “cific ncRNAs in cancer suggest that ncRNAs may be useful targets (27).”