Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/β-secretase expression
By Sébastien S. Hébert, Katrien Horré, Laura Nicolaï, Aikaterini S. Papadopoulou, W. Mandemakers, Asli Silahtaroglu, Sakari Kauppinen, A. Delacourte, B. de Strooper. Proceedings of the National Academy of Sciences of the United States of America, 2008
1,190 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/17fa884ab71e069d7464a1839a23bba569f84b9b
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In Cancer Research
- Danish H Sayed
- Yu Li
- Qinghua Cui
- Kris V. Kowdley
- A. Ardekani
- Mozhgan Moslemi Naeini
- M. Abdellatif
- Xing Chen
In Molecular Biology
- Danish H Sayed
- Yu Li
- Qinghua Cui
- Kris V. Kowdley
- A. Ardekani
- Mozhgan Moslemi Naeini
- M. Abdellatif
- Xing Chen
In Physiology
Citations in the corpus
- The Role of MicroRNAs in Human Diseases (2010, background): “For example, loss of miR-29 cluster has been shown to be associated with increased (beta-amyloid precursor protein-converting enzyme) BACE1/ beta-secretase expression in sporadic AD patients (136) .”
- Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “Among these are miR-107, miR-298, miR-328, and the miR-29a/b-1 cluster (Hebert et al. 2008).”
- An Analysis of Human MicroRNA and Disease Associations (2008, result): “Later research revealed that miR-9 is associated with Alzheimer’s disease[24], which supported our prediction.”
- Neuroinflammation as a Common Feature of Neurodegenerative Disorders (2019, background): “…since previous research has pointed out that REM sleep disturbances could be associated with the formation of aggregated forms of the proteins already discussed, promoting the mechanisms underlying the inflammatory context (Hebert et al., 2008; Leidinger et al., 2013; Nagaraj et al., 2017).”
- MicroRNAs in Common Human Diseases (2012, background): “More specifically, the expression of miR-29a, miR-29b-1 and miR-9 was significantly decreased in AD patients [95], resulting in abnormally high expression of their target BACE1, a protein playing an important role in AD pathogenesis [96].”
- MicroRNAs in development and disease. (2011, background): “In contrast, miR-29b is downregulated in sporadic AD patients and inversely correlates with BACE1 expression (241).”