Human tRNA-derived small RNAs in the global regulation of RNA silencing.

By D. Haussecker, Yong Huang, Ashley Lau, Poornima Parameswaran, A. Fire, M. Kay. RNA: A publication of the RNA Society, 2010

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An overview of microRNAs (2015, background): “Another class is derived from outside the mature tRNA and is generated by the tRNA splicing reaction[89, 90].”
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage. (2010, background): “Defined tRNA fragments have been identified through small RNA cloning approaches (Kawaji et al. 2008; Cole et al. 2009; Haussecker et al. 2010), suggesting a physiological role for tRNA fragments.”
The human mitochondrial transcriptome (2011, unknown): “It was recently shown that nuclear tRNAs are processed by both Dicer-and RNaseZ-dependent pathways into a range of small RNA species that are subsequently incorporated into RNA-silencing pathways (Haussecker et al., 2010; Lee et al., 2009).”
Angiogenin-induced tRNA fragments inhibit translation initiation (2011, background): “After incubation, immobilized biotinylated RNA-streptavidin complexes were washed twice with RNase-free wash buffer II (15 mM Tris HCl [pH 7.2], 750 mM NaCl, 1 mM EDTA, 0.1% NP-40) and once with icecold RNase-free wash buffer I (15 mM Tris HCl [pH 7.2], 150 mM NaCl, 1 mM EDTA, 0.1% NP-40”
The rise of regulatory RNA (2014, background): “There are also intriguing and recurring reports of fragments of tRNAs produced in tissue-specific patterns 119 and associated with Ago proteins 120 .”