Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

By W. Pang, E. Price, D. Sahoo, Isabel Beerman, W. Maloney, Derrick J. Rossi, S. Schrier, Irving L. Weissman. Proceedings of the National Academy of Sciences of the United States of America, 2011

913 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8f92a8adbd93b66892015cf046d5d3096e04b113

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Citations in the corpus

• Variation in cancer risk among tissues can be explained by the number of stem cell divisions (2015, neutral): “Published 2 January 2015, Science 347, 78 (2015)”
• Measuring biological aging in humans: A quest (2019, neutral): “…(Dexheimer, Mueller, Braatz, & Richter, 2011; Eichler et al., 2017; Fan et al., 2010; Golpanian et al., 2017, 2016; Hare et al., 2012; Jim et al., 2016; Li, Chen, Han, & Fu, 2010; Pang et al., 2011; Rigotti et al., 2016; Tompkins et al., 2017; Volarevic et al., 2011, 2018; Zhang et al., 2011).”
• Human Bone Marrow Assessment by Single Cell RNA Sequencing, Mass Cytometry and Flow Cytometry (2018, background): “Discussion Changes in the immune system (14) and hematopoiesis (18) occur during human aging.”
• Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults (2016, neutral): “This hypothesis may also explain why HSPC number increases and quiescence decreases as a function of age 24,25 .”
• Immunosenescence: molecular mechanisms and diseases (2023, background): “In both mouse and human models, the hematopoietic stem cell (HSC) population of aged individuals had an increased frequency of immunophenotypes, was less quiescent, and showed myeloid-biased potentials, with transcriptional upregulation of genes related to cell cycle, myeloid-biased differentiation ”
• Inflammation and aging: signaling pathways and intervention therapies (2023, background): “This leads to a reduction in the number of precursors for T and B cells with increasing age.(108,109) Taken together, with aging, the number of HSCs increases, while their function including self-renewal and clonogenicity, decreases.”
• Causes, consequences, and reversal of immune system aging. (2013, neutral): “This shift has been correlated with increased expression of myeloid lineage genes and downregulation of those specifying a lymphoid lineage fate (11, 17).”