Hematopoiesis: an evolving paradigm for stem cell biology.

By Stuart H. Orkin, Leonard I. Zon. Cell, 2008

2,582 citations recorded by the source corpus.

Subfields: Cell Biology, Hematology, Physiology

View Paper: https://www.semanticscholar.org/paper/f9d9b211f4bef99589d0d61de41764207143dd6b

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Citations in the corpus

Mechanisms of stem cell self-renewal. (2009, background): “A balance among lineage-specification genes that promote alternative fates may suppress differentiation by mutual inhibition (Orkin & Zon 2008).”
Origin and Functions of Tissue Macrophages (2014, background): “Only in the perinatal period do traditional bone marrow HSCs become the primary site of hematopoiesis and produce the full complement of immune lineages (Orkin and Zon, 2008).”
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation (2014, background): “The latter takes place in the fetal liver, which is initially seeded by hematopoietic progenitors from the yolk sac and subsequently by HSCs from endothelium of the aorta-gonads-mesonephros (80, 81).”
Hematopoietic stem cell quiescence promotes error prone DNA repair and mutagenesis (2010, background): “The hematopoietic system provides a uniquely tractable model to investigate the activity of specific cell populations (Orkin and Zon, 2008).”
Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. (2015, background): “…lineages is contingent upon activation of specific and tightly regulated gene expression programs, orchestrated by lineagedetermining transcription factors (TFs) (Cantor and Orkin, 2002; Graf and Enver, 2009; Moignard et al., 2013; Orkin et al., 1998; Orkin and Zon, 2008; Pevny et al., 1991).”
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis (2012, neutral): “Myeloid cells, including mononuclear phagocytes, are known to arise from two successive hematopoetic waves, referred to as 'primitive' and 'definitive', respectively (Orkin and Zon, 2008).”
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells (2011, background): “Extracellular fluid apparently regulates the microenvironment of hematopoietic stem cells, where Igf signaling regulates progenitor proliferation (Orkin and Zon, 2008; Zhang and Lodish, 2004).”
INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, neutral): “In mammals, macrophages develop from precursors that arise during multiple waves of embryonic hematopoiesis, occurring initially within extraembryonic yolk sac tissue and then subsequently in the aortic endothelium of the aorta-gonad-mesonephros region and in the placenta, fetal liver, and bone marr”
Densely interconnected transcriptional circuits control cell states in human hematopoiesis (2011, neutral): “For example, the circuit of HSC-expressed TFs with known binding sites (Figure 5A) includes many major known regulators of the HSC state (Orkin and Zon, 2008), which are densely interconnected through autoregulatory (12 of 23 active factors), feedback (15 and 39 loops of size 2 and 3), and…”
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening. (2017, neutral): “These observations are consistent with the model that myeloid leukemias suffer from a block in terminal differentiation arising as a result of aberrant TF activity (Orkin and Zon, 2008; Rosenbauer and Tenen, 2007).”