The impact of translocations and gene fusions on cancer causation

By F. Mitelman, B. Johansson, F. Mertens. Nature Reviews. Cancer, 2007

1,395 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/6f469ec0a2fef6fd65309a02cc931026177ddfb2

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Citations in the corpus

MM-align: a quick algorithm for aligning multiple-chain protein complex structures using iterative dynamic programming (2009, background): “gene-fusions (20) or aligning proteolytically cleaved chains to an uncleaved chain].”
deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data (2011, background): “ETS gene fusions are present in 80% of malignancies of the male genital organs, and as a result these fusions alone are associated with 16% of all cancer morbidity [2].”
The emerging complexity of gene fusions in cancer (2015, background): “First specific chromosome change in neoplasia: Philadelphia chromosome detected in CML7 First characteristic translocations in leukaemia: t(9;22)(q34;q11) in CML and t(8;21)(q22;q22) in AML9,10 First characteristic translocations in experimental tumours: t(6;15) and t(12;15) in MPC18”
RNA sequencing: advances, challenges and opportunities (2010, background): “Gene fusion detection RNA-seq combined with computational analyses analogous to the ones described above for splice-site detection can also be used to identify gene fusion events in disease tissues, which has particular importance for cancer researc”
KIF5B-ALK, a Novel Fusion Oncokinase Identified by an Immunohistochemistry-based Diagnostic System for ALK-positive Lung Cancer (2009, background): “chronic myelogenous leukemia (2), has thus been followed by the discovery of many fusion-type oncogenes (3).”
The EML4‐ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild‐type EGFR and KRAS (2009, background): “Chromosomal translocation has long been linked to cancer causation(3) and is related to approximately 20% of all cancers.(4) Fusion genes are common in lymphoid, hematopoietic, and connective tissue cancers; however, apart from prostatic carcinoma, it is believed that fusion genes are rare in solid ”
The impact of a negligent G2/M checkpoint on genomic instability and cancer induction (2007, background): “Chromosomal aberrations, including chromosome breaks or rearrangements, are reflective of genomic instability and are a hallmark of cancer cell”
COMPLEX LANDSCAPES OF SOMATIC REARRANGEMENT IN HUMAN BREAST CANCER GENOMES (2009, neutral): “point in copy number identified by the segmentation algorithm; (3) reads mapping $600 bp apart spanned by $2 read-independent read pairs (where at least one read pair had an alternative mapping quality $35) with both ends mapping to”
Androgen-induced TOP2B mediated double strand breaks and prostate cancer gene rearrangements (2010, background): “613" language="eng" relation="no"> Genomic rearrangements that create cell-type-specific fusion oncogenes are hallmarks of cance”
BreakDancer: An algorithm for high resolution mapping of genomic structural variation (2009, neutral): “Instances of structural variants in germ and somatic cells contribute respectively to heritable genetic diseases 2,3 and cancers 4-6 .”
Maximizing mouse cancer models (2007, background): “In some cases, the junctions of these translocations are known and the resulting fusion gene products are well-characterize”
Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck (2009, background): “Most fusion genes identified thus far have been in hematological disorders and mesenchymal neoplasms, and only a few have been found in carcinomas (1).”