The EML4‐ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild‐type EGFR and KRAS

By D. Wong, Elaine Lai‐Han Leung, Kimpton Kam‐Ting So, Issan Yee San Tam, A. Sihoe, L. Cheng, Kwok‐Keung Ho, J. Au, L. Chung, Maria Pik Wong. Cancer, 2009

757 citations recorded by the source corpus.

Subfields: Cell Biology, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/42efeb06ce3edf3bc83e542dadf897fe9949fc00

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In Cell Biology

J. Settleman

In Oncology

In Pulmonary and Respiratory Medicine

Citations in the corpus

Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. (2009, background): “One recent study of EML4-ALK in Asian patients with NSCLC noted a nonstatistically significant trend toward younger median age.(17) Interestingly, several other cancers known to harbor ALK rearrangements, such as anaplastic large cell lymphomas, neuroblastomas, and inflammatory myofibroblastic tumor”
Unique Clinicopathologic Features Characterize ALK-rearranged Lung Adenocarcinoma in the Western Population (2009, background): “We found that the incidence of ALK -rearranged tumors in our surgically resected specimens from unselected groups of patients is 0.45%, which is lower that that reported for the Asian cohorts also consisting of surgically resected cases (28,33).”
Brigatinib versus Crizotinib in ALK‐Positive Non–Small‐Cell Lung Cancer (2018, neutral): “Increased blood creatinine level 3 (2) 0 19 (14) 1 (1)”
Targeted therapy for non-small cell lung cancer: current standards and the promise of the future. (2015, background): “As with EGFR, ALK rearrangements are more likely to be seen in specific populations; younger patients who are light or never-smokers with adenocarcinoma and frequent signet ring cells seen on histology (97-101).”
Identification of a Novel Biomarker, SEMA5A, for Non–Small Cell Lung Carcinoma in Nonsmoking Women (2010, background): “Cancer Res 2008; :6913–21. ng DW, Leung EL, So KK, et al. The EML4-ALK fusion gene is olved in various histologic types of lung cancers from nonsmokers h wild-type EGFR and KRAS.”