Maximizing mouse cancer models

By K. Frese, D. Tuveson. Nature Reviews. Cancer, 2007

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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase (2009, background): “Progress within the last decade has led to the sophisticated engineering and application of advanced preclinical models of human cancer in the mous”
p53 polymorphisms: cancer implications (2009, background): “It allows testing of in vitro hypotheses in an in vivo context, with the caveat that some components of the p53 network will differ in mice and men, so the design of the models has to be based on knowledge of the underlying molecular biolog”
Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008, background): “The generation of novel conditional alleles of Rb and other cancer genes, using a combination of Cre–lox, Flp–frt and tetracycline-inducible system”
Paul Ehrlich's magic bullet concept: 100 years of progress (2008, methodology): “Appropriate animal tumour models, (as originally studied by Ehrlich and Apolant), in vitro models for mechanism-based toxicity and molecularly defined targeted disruption of cancer genes in animal models are important tools for a better prediction of side-effect”