Evolutionary Medicine: From Dwarf Model Systems to Healthy Centenarians?

By V. Longo, C. Finch. Science, 2003

600 citations recorded by the source corpus.

Subfields: Aging, Genetics, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/6e6f89987f349f0caf24b2fa95cd21884f46666b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. V. Longo
2. R. Ricklefs
3. D. Klionsky
4. Brian K. Kennedy
5. J. Campisi
6. G. O'Connor
7. Guido Kroemer
8. P. Distefano

In Genetics

1. D. Klionsky
2. J. Campisi
3. R. Ricklefs
4. Guido Kroemer
5. David B. Allison
6. Lecture Notes

In Pediatrics, Perinatology and Child Health

1. D. Klionsky
2. R. Ricklefs
3. J. Campisi

Citations in the corpus

• Sirtuins in aging and age-related disease. (2006, background): “…in S. cerevisiae and invertebrate model systems, coupled with similarities between Sirt1-deficient and long-lived IGF-I-deficient dwarf mice (Longo and Finch, 2003), suggest that the safest bet at this point is that Sir2 deacetylases play both pro- and anti-aging roles in different contexts.”
• Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy (2012, background): “Fasting apparently protects normal cells by reallocating energy toward maintenance pathways from reproduction and growth processes when nutrients are scarce or absent (2, 10, 13, 15).”
• Growth Hormone Receptor Deficiency is Associated With a Major Reduction in Pro-aging Signaling, Cancer and Diabetes in Humans (2011, unknown): “Pathways that normally regulate growth and metabolism also promote aging and genomic instability, a correspondence that is conserved in simple eukaryotes and mammals (7, 16-18).”
• The molecular machinery of autophagy: unanswered questions (2005, background): “Autophagy is also associated with the extension of lifespan that correlates with caloric restriction (Bergamini et al., 2003; Longo and Finch, 2003; Melendez et al., 2003; Vellai et al., 2003).”
• Physiological frailty index (PFI): quantitative in-life estimate of individual biological age in mice (2017, unknown): “Long-lived calorie-restricted mice and IGF-1 knockout mice develop multiple health deficits [27, 28].”
• Cancer is a Preventable Disease that Requires Major Lifestyle Changes (2008, background): “CR in rodents decreases the levels of plasma glucose and IGF-1 and postpones or attenuates cancer and inflammation without irreversible adverse effects ( 120 ).”
• Thyroid status, disability and cognitive function, and survival in old age. (2004, background): “Moreover, caloric restriction is known to prolong life in rodent models, an effect that may be the result of lower thyroid function and a lower metabolic rate.(37-39) It is not known whether mild hypothyroidism in elderly individuals, commonly caused by autoimmune thyroiditis, has a similar effect o”
• The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. (2004, methodology): “A common method to limit energy is dietary restriction, which leads to lifespan extension in organisms as diverse as yeasts, nematodes, and rodents (Lakowski and Hekimi 1998; Longo and Finch 2003).”
• A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice (2008, background): “Some of the phenotypes that are observed in animals with altered IGF-1 or insulin signaling are also observed in CR mice, such as reduced levels of IGF-1, insulin and glucose [18].”
• Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. (2005, background): “The wounding response also (entails local inflammation, a frequent occurrence in aging ttissues and proposed initiating or causative factor in a Svariety of age-related diseases, including atherosclerocsis and cancer (Longo and Finch, 2003).”
• A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance and healthspan (2015, background): “…metabolic and cellular changes that affect oxidative damage and inflammation, optimize energy metabolism, and enhance cellular protection (Haigis and Yankner, 2010; Johnson et al., 2000; Lee et al., 2012b; Longo and Finch, 2003; Mair and Dillin, 2008; Narasimhan et al., 2009; Smith et al., 2008).”
• Induction of autophagy by spermidine promotes longevity (2009, background): “Chronological ageing of yeast cells follows molecular pathways that are shared with those dictating longevity of non-dividing post-diauxic cells of higher eukaryote”
• Insulin-like growth factors and neoplasia (2004, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3479">IGF1 ) signalling pathway arose early in evolution, possibly as a regulator of cellular proliferation in relation to nutrient availabilit”